Klinische Pädiatrie
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Klinische Pädiatrie · Mar 1987
Case Reports[Successful peritoneal dialysis in a premature infant with a birth weight of 850 grams--a case report].
A very low birth weight (850 g) premature infant developed a life threatening hyperkalemia and cardiac dysrhythmia on the first day of life. Standard treatment of hyperkalemia with calcium, dextrose-insulin, sodium-polystyrene sulfonate was ineffective. ⋯ The baby is now nine months old and physically and mentally well developed. This case report should encourage the prompt decision for a peritoneal dialysis even in the very low birth weight infant if dangerous metabolic derangements are otherwise unamenable to treatment.
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Klinische Pädiatrie · Jul 1986
Case Reports[Transitory pseudohypoparathyroidism in the newborn infant].
This is a report on two young infants suffering from transitory pseudohypoparathyroidism. Therapy with vitamin D in high doses was not helpful but metabolic changes were promptly corrected by the administration of 1.25-(OH)2-D3 (Rocaltrol). ⋯ Treatment with 0.25 and 0.5 micro-Gram 1.25-(OH)2-D3 respectively resulted in prompt correction of serum calcium- and serum-phosphate-changes. The observation of the urinary-cAMP-excretion during the course of the disease enables one to differentiate between the permanent and the transient form of the disease: values reaching 5-10 nmol/mg Creatinine indicate the time when treatment can be discontinued in the transitory form.
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Klinische Pädiatrie · May 1985
Randomized Controlled Trial Comparative Study Clinical Trial[Results of the COSS-77 and COSS-80 studies on adjuvant chemotherapy in osteosarcoma of the extremities].
In the first study, COSS-77, 100 patients with OS were treated for 12 months according to a CT-protocol consisting of high-dose methotrexate (HD-MTX), adriblastine (ADR) and cyclophosphamide (CP). At 40 months the expected continuous disease-free survival (CDFS) rate of the 71 evaluable patients was 55%. After exclusion of local recurrences (n = 2) and fatal chemotherapy toxicities (n = 0) a reduced group of 69 patients remained and the expected CDFS rate at 40 months became 56%. ⋯ This is significantly better (p less than 0.05) than the results obtained from the COSS-77 group. No differences were found between the CPL and BCD arms of the COSS-80 group or between the arms receiving or not receiving IF. A significant increase in the CDFS rate for young (less than 12 years) and male patients over that in COSS-77 was observed in COSS-80, probably due to the increased MTX dose.(ABSTRACT TRUNCATED AT 250 WORDS)
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Patients with cystic fibrosis of the pancreas show an incidence of diabetes mellitus tenfold higher than is found in the general pediatric population. Considering this fact glucagon and insulin responses to oral glucose and intravenous arginine were studied in 22 CF children and adolescents. Some investigated patients had suffered from the disease for ten years and more. ⋯ This may be a consequence of impaired affinity of the specific target cell receptors. The insulin secretion pattern is proven to be identical to that of chemical diabetes mellitus in adults. Quantitative diminution in arginine stimulated insulin-output has been found to be independent of the degree of carbohydrate intolerance.(ABSTRACT TRUNCATED AT 250 WORDS)
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Klinische Pädiatrie · Nov 1984
Case Reports[Central venous air embolism in an artificially respirated premature infant with respiratory distress syndrome].
We report a 935 g 27 weeks gestational age male infant born to a 30 year old mother on chronic intermittent hemodialysis for three years prior to the pregnancy. Immediately after birth the infant presented with severe respiratory distress requiring mechanical ventilation. Chest x-ray showed severe hyaline membrane disease with interstitial emphysema. The infant developed a left tension pneumothorax and systemic air embolism of the right heart, the inferior and superior vena cava and the hepatic vein, from which it subsequently died about 12 h later.