Klinische Pädiatrie
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Klinische Pädiatrie · Mar 2010
Randomized Controlled Trial Comparative StudyComparison of sufentanil versus fentanyl in ventilated term neonates.
Increasingly frequent applications of opioid analgesics in neonatal intensive care require the evaluation of efficacy and side effects. ⋯ In our study sufentanil did not reduce the weaning period in ventilated term neonates when compared to fentanyl. The equipotent dose ratio for fentanyl/sufentanil was 10:1. According to sedation scores both substances provided effective pain and stress protection.
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Klinische Pädiatrie · Nov 2009
Randomized Controlled Trial Multicenter Study Comparative StudyDose reductions of vincristine in children with medulloblastoma treated in the maintenance arm of the prospective multicenter trial HIT'91.
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Klinische Pädiatrie · Nov 2008
Randomized Controlled Trial Multicenter StudyAcupuncture to alleviate chemotherapy-induced nausea and vomiting in pediatric oncology - a randomized multicenter crossover pilot trial.
We investigated whether acupuncture as a supportive antiemetic approach reduces the need for antiemetic rescue medication during highly emetogenic chemotherapy in pediatric oncology. We report on a multicenter crossover study at 5 tertiary hospitals in Germany. ⋯ Acupuncture as applied here seems to be effective in preventing nausea and vomiting in pediatric cancer patients.
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Klinische Pädiatrie · May 2004
Randomized Controlled Trial Multicenter Study Comparative Study Clinical TrialResults of the SIOP 93-01/GPOH trial and study for the treatment of patients with unilateral nonmetastatic Wilms Tumor.
The treatment of Wilms Tumor is integrated into clinical trials since the 1970's. In contrast to the National Wilms Tumor Study Group (NWTSG) the SIOP trials and studies largely focus on the issue of preoperative therapy to facilitate surgery of a shrunken tumor and to treat metastasis as early as possible. ⋯ Patients with unilateral Wilms tumor without metastasis have an excellent prognosis. The post-operative chemotherapy in stage I can be reduced to 4 weeks without worsening treatment outcome. The reduction of the tumor volume could be identified as a helpful marker for stratification of post-operative treatment. Post-chemotherapy blastemal predominant subtype of Wilms tumor has to be classified as high risk tumor. Focal anaplasia has a better prognosis than diffuse anaplasia and will be classified as intermediate risk tumor.
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Klinische Pädiatrie · Mar 2003
Randomized Controlled Trial Comparative Study Clinical TrialGamma-hydroxybutyrate versus chlorprothixene/phenobarbital sedation in children undergoing MRI studies.
Few clinical studies have assessed gamma-hydroxybutyrate and chlorprothixene/phenobarbital sedation in children. This prospective trial compared the two regimes in children, in particular concerning differences in recovery time. ⋯ Due to its significantly shorter recovery time, gamma-hydroxybutyrate is a reasonable sedative drug for children undergoing non-invasive diagnostic procedures, and is superior to chlorprothixene/phenobarbital. In pediatric oncology patients gamma-hydroxybutyrate appears to be associated more often with vomiting. The long recovery time and its great variability make chlorprothixene/phenobarbital a less valuable alternative.