Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]
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Local failure is the one of the most frequent cause of tumor related death in locally advanced non-small cell lung cancer (LAD-NSCLC). Dose escalation has the promise of increased loco-regional tumor control but is limited by the tolerances of critical organs. ⋯ IMRT gives the possibility of further dose escalation without an increasing mean lung dose especially in patients with large tumors.
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The aim of this study was to evaluate effect, toxicity, and cosmesis of a prospectively applied pulsed dose rate (PDR) brachytherapy boost schedule in patients with stage I/II/IIIa invasive breast cancer. ⋯ PDR brachytherapy is safe, effective, and provides good cosmesis. A CLDR breast boost can be replaced by PDR brachytherapy without significant loss of therapeutic ratio.
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Different radiotherapy techniques are used for postmastectomy irradiation. We review the results with the electron-beam-rotation technique in advanced breast cancer patients. Main endpoint was local tumor control. ⋯ In high-risk breast cancer patients postmastectomy irradiation with the electron-beam-rotation technique is an effective therapy, resulting in a 5-year local failure rate of 8%. Intensified local therapy needs further investigation in subgroups of patients with additional risk factors.
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Comparative Study
Biochemical response after 3-d conformal radiotherapy of localized prostate cancer to a total dose of 66 gy 4-year results.
Since the introduction of 3-D conformal radiotherapy (CRT) doses of /= 70 Gy should be considered. As a consequence of our earlier analysis a prospective multicenter treatment optimization protocol has been initiated in 1999. The protocol includes a risk-adapted dose increase from 70 Gy in low-risk patients to 74 Gy in high-risk patients including short-term androgen ablation.
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Patients with metastatic spinal cord compression are often presented for emergency radiotherapy. The optimum radiotherapeutic regimen is still debated, studies comparing different radiation schedules on therapeutic outcome are scarce. This analysis compares the effect of two schedules on motor function considering three relevant prognostic factors (type of primary tumor, pre-treatment ambulatory status, time of developing motor deficits before radiotherapy). ⋯ The two radiation schedules were comparable for functional outcome. The less time consuming schedule (30 Gy/10 fractions) can be recommended in metastatic spinal cord compression, as life expectancy is markedly reduced in the majority of these patients.