Nutrition
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This study aimed to compare the accuracy of four machine-learning (ML) algorithms, using two classification schemes, to predict undernutrition based on individual and household risk factors. ⋯ The random forest algorithm performed best in predicting undernutrition among Filipino elementary schoolchildren, although results could be improved with bootstrap aggregation. The AMDR classification shows potential for targeting feeding beneficiaries. However, local dietary culture should be considered in the development of nutrition interventions. Government use of big-data techniques such as ML must also address underrepresentation in health data collected from and accessible to poor populations or risk further marginalizing them.
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Comparative Study
Comparison of the effects of different dietary regimens on susceptibility to experimental acute kidney injury: The roles of SIRT1 and TGF-β1.
Mortality due to acute kidney injury (AKI) is high despite its reversibility, and studies on efficient treatments for accelerating the recovery of or preventing AKI are of great significance. The amount of daily calorie intake and how it is taken affect body organs and how cells respond to it. The aim of this study was to determine the effects of four types of diets: calorie restriction (CR), time-restriction eating (TR), intermittent fasting (IF), and high-fat diet (HF), on renal injury indicators in male rats. ⋯ The results of the present study showed that CR and TR can be introduced as a treatment method to prevent AKI. These diets can increase the resistance of kidney cells against injuries, possibly by increasing SIRT1, decreasing TGF-β1, and improving antioxidant status; and they have renoprotective effects.
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Muscle wasting is a common complication in patients with nonalcoholic fatty liver disease (NAFLD). In this study, we investigated the effect of NAFLD on satellite cell (SC) content and skeletal muscle repair. ⋯ The findings demonstrate that a decrease in SC content in the skeletal muscle is an important factor that contributes to muscle wasting in NAFLD. Thus, preservation of the muscle SC pool is a potential therapeutic strategy to reduce NAFLD-associated muscle wasting.