Nutrition
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We aimed to investigate the effect of iron deficiency on basal- and contraction-induced increases in muscle protein synthesis. ⋯ These results suggest that severe iron deficiency decreases not only basal but also muscle contraction-induced increases in protein synthesis due to, at least in part, downregulation of the protein synthesis signaling pathway in the skeletal muscle.
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In India, although nutritional conditions have improved, a high prevalence of anthropometric failure is still reported in children. Unfortunately, there are knowledge gaps surrounding nutrient and anthropometric shortcomings as well as dietary patterns. More than half of children are consuming a vegetarian diet. This study aimed to evaluate the effects of dietary adequacy levels on anthropometric failure in 5772 vegetarian children (ages 6-23 mo) satisfying minimum dietary diversity. ⋯ Dairy is an essential source of nutrients that are required for healthy growth and development in children younger than 2 y, even if they satisfy minimum dietary diversity conditions in India.
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Milk provide protective effects against bone loss caused by an impaired calcium balance. Although the effects of some elements have previously been confirmed, the involvement of milk basic protein (MBP) in bone mineral metabolism remains poorly characterized. Moreover, the importance of mineral nutrition sufficiency to establish the effect of MBP must be evaluated. ⋯ Therefore, adaptive calcium homeostasis is an essential requirement when MBP exerts protective effects through the inhibition of bone resorption.
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Molluscum contagiosum (MC) is viral skin infection that is most commonly observed in children. Zinc homeostasis is essential for proper immune function, especially in host-virus interactions. This study aimed to investigate the effectiveness of oral zinc sulfate treatment in children with MC. ⋯ Our findings support the use of oral zinc sulfate as a therapy for children with MC.
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Acute kidney injury (AKI) is a severe complication of rhabdomyolysis that significantly increases mortality. Unfortunately, the therapeutic approach is limited. Inflammation plays a critical role in the pathogenesis of rhabdomyolysis-induced AKI, which is a potential therapeutic target. Nicotinamide, a form of vitamin B3 and a precursor of nicotinamide adenine dinucleotide, has been shown to have potent antiinflammation effects. Klotho is a tubular highly expressed renoprotective protein. Therefore, we explored the effect of nicotinamide on rhabdomyolysis-induced AKI and the underlying mechanisms. ⋯ Our study demonstrated that Klotho preservation is essential for the renoprotection effect of nicotinamide, and provides a new preventive strategy for rhabdomyolysis-induced AKI.