Journal of clinical anesthesia
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Comparative Study Clinical Trial
A comparison of propofol and remifentanil during monitored anesthesia care.
To compare remifentanil, an esterase-metabolized opioid, to a standard propofol-based sedation technique for monitored anesthesia care (MAC). ⋯ Remifentanil provided comparable intraoperative conditions and patient comfort at a lower sedation level compared with propofol. However, remifentanil was associated with greater respiratory depression and a longer time to home readiness.
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Comparative Study Clinical Trial
Pipecuronium revisited: dose-response and maintenance requirement in infants, children, and adults.
To compare dose-response relationship and maintenance requirement of pipecuronium in anesthetized infants, children, and adults. ⋯ Bolus dose requirement of pipecuronium is greatest in children. Maintenance requirement is related to potency in each age group studied.
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To obtain data about the safety and efficacy of the size 5 laryngeal mask airway (LMA), which is a scaled-up version of the size 4 and is generally recommended for patients over 90 kg, for positive pressure ventilation (PPV), ease of insertion, oropharyngeal and gastric insufflation pressures, fiberoptic positioning, and complication rates. ⋯ Positive pressure ventilation with the size 5 LMA is safe and effective with a low failure/problem rate using tidal volumes of 8 to 10 ml/kg, even in those patients who are moderately obese. The device is suitable for patients weighing under 90 kg in whom the seal with the size 4 is inadequate.
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
Effects of intravenous and oral clonidine on hemodynamic and plasma-catecholamine response due to endotracheal intubation.
To investigate the effects of intravenous (IV) versus oral clonidine on alterations of heart rate (HR), mean arterial pressure (MAP), cardiac output (CO), and plasma-catecholamines due to endotracheal intubation. ⋯ In conclusion, IV clonidine reduced stress response to endotracheal intubation compared with placebo. Oral clonidine at the dose used was less effective in blunting hemodynamic stress response than IV clonidine.