Journal of clinical anesthesia
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Randomized Controlled Trial Clinical Trial
Dexmedetomidine premedication before intravenous regional anesthesia in minor outpatient hand surgery.
To assess the efficacy and safety of intravenous (i.v.) dexmedetomidine, an alpha-2 agonist, as a premedication before i.v. regional anesthesia. ⋯ Dexmedetomidine is an effective premedication before i.v. regional anesthesia because it reduces patient anxiety, sympathoadrenal responses, and opioid analgesic requirements.
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Randomized Controlled Trial Comparative Study Clinical Trial
Transarterial brachial plexus anesthesia for hand surgery: a retrospective analysis of 346 cases.
To study the safety and efficacy of the transarterial approach to brachial plexus block with 60 to 70 ml of local anesthetic solution, and to compare the success and complication rates of this block performed by experienced or inexperienced anesthesiologists. ⋯ Transarterial brachial plexus block administered with a 60 to 70 ml dose of local anesthetic provides surgical analgesia for hand surgery with an excellent success rate and without serious adverse effects.
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Randomized Controlled Trial Clinical Trial
Clinical pharmacokinetics of propofol given as a constant-rate infusion and in combination with epidural blockade.
To investigate the pharmacokinetics of propofol in combination with epidural anesthesia or with intravenous (i.v.) alfentanil infusion, and to investigate the clinical feasibility of this anesthetic technique in lower abdominal surgery. ⋯ We could not show any statistically significant influence of an epidural blockade on the pharmacokinetic parameters of propofol. Nevertheless, the concentration-time profile changed during infusion, rendering the described infusion regimen, in combination with epidural anesthesia, unsatisfactory for adequate hypnosis. The propofol infusion regimen combined with alfentanil provided immediate and stable blood concentrations that were adequate for surgery.
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Randomized Controlled Trial Clinical Trial
Changes in end-tidal carbon dioxide during gynecologic laparoscopy: spontaneous versus controlled ventilation.
To study the changes in PETCO2 during spontaneous and controlled ventilation in patients undergoing gynecologic laparoscopy. ⋯ In view of the high PETCO2 levels, spontaneous breathing should be avoided during gynecologic laparoscopy, and ventilation to an initial PETCO2 of 4 kPa (30 mmHg) is recommended during controlled ventilation.
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Randomized Controlled Trial Clinical Trial
The effect of d-tubocurarine priming on an ED95 dose of vecuronium bromide.
To examine how priming with ED10 d-tubocurarine prior to the administration of ED95 vecuronium bromide affects onset and duration of neuromuscular blockade. ⋯ These results indicate that crossover dosing of nondepolarizing muscle relaxants may have synergistic effects. Priming with ED10 d-tubocurarine prior to an ED95 dose of vecuronium shortens the time to 80% T1 depression and produces satisfactory intubating conditions at 90 seconds, without prolonging the duration of the Therefore, d-tubocurarine is an attractive drug for priming vecuronium in short operative procedures that require muscle relaxation.