Der Schmerz
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This manuscript reviews some aspects of the unorthodox development of analgesics. Most of them were not discovered by systematic research for analgesics; rather they were developed primarily as antipyretic or antirheumatic drugs that later became analgesics due to clinical observations. ⋯ These drawbacks limit the discovery of new analgesics. On the other hand, modern insights into the site of action and the mode of action of antipyretic analgesics are likely to further the discovery of new and better analgesics.
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[Development of a screening questionnaire to predict good and poor outcome of lumbar disc surgery.].
The aims were: (1) to investigate the prognostic value of pain history, sociodemographic, psychodiagnostic and medical factors for long-term outcome after lumbar disc surgery and (2) to develop a screening checklist of reliable predictors that distinguish between good and poor outcomes. ⋯ It is possible to determine for each patient a predictor sum that is prognostic for the individual risk of a poor operation outcome.