Acta neurologica Scandinavica
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Acta Neurol. Scand. · Dec 2020
Neuropsychological tests are useful for predicting comorbidities of idiopathic normal pressure hydrocephalus.
Comorbidities of idiopathic normal pressure hydrocephalus (iNPH), such as Alzheimer's disease (AD) and Parkinson's spectrum (PS) disorder, can affect the long-term prognosis of cerebrospinal fluid (CSF) shunting. Therefore, it is important to be able to predict comorbidities in the early stage of the disease. This study aimed to predict the comorbidities of iNPH using neuropsychological tests and cognitive performance evaluation. ⋯ The 4 neuropsychological tests of the EU-iNPH-scale can help predict iNPH comorbidities and evaluate the prognosis of CSF shunting.
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Acta Neurol. Scand. · Dec 2020
Meta AnalysisCannabidiol efficacy independent of clobazam: Meta-analysis of four randomized controlled trials.
The efficacy of cannabidiol (CBD) with and without concomitant clobazam (CLB) was evaluated in stratified analyses of four large randomized controlled trials, two in Lennox-Gastaut syndrome, and two in Dravet syndrome. ⋯ These results indicate CBD is efficacious with and without CLB, but do not exclude the possibility of a synergistic effect associated with the combination of agents. The safety and tolerability profile of CBD without CLB show a lower rate of certain AEs than with CLB.
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Acta Neurol. Scand. · Dec 2020
Critical illness polyneuromyopathy: Functional impact after severe acquired brain injuries.
Critical illness polyneuropathy and myopathy (CIPNM) frequently affects critical patients and can occur after severe acquired brain injuries (sABI) influencing the functional recovery. We aimed to assess how the concomitance between CIPNM and sABI might influence the rehabilitative outcomes in terms of functional autonomy, oral feeding recovery and endotracheal tube weaning. ⋯ CIPMN significantly affects the rehabilitative outcomes after a sABI and should be taken into account for better rehabilitative handling.