Acta neurologica Scandinavica
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Acta Neurol. Scand. · Dec 2020
Meta AnalysisCannabidiol efficacy independent of clobazam: Meta-analysis of four randomized controlled trials.
The efficacy of cannabidiol (CBD) with and without concomitant clobazam (CLB) was evaluated in stratified analyses of four large randomized controlled trials, two in Lennox-Gastaut syndrome, and two in Dravet syndrome. ⋯ These results indicate CBD is efficacious with and without CLB, but do not exclude the possibility of a synergistic effect associated with the combination of agents. The safety and tolerability profile of CBD without CLB show a lower rate of certain AEs than with CLB.