Acta neurologica Scandinavica
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Acta Neurol. Scand. · May 2012
Absence of cardiovascular disease risk factors in restless legs syndrome.
Restless legs syndrome (RLS) might represent a condition at risk of cardiovascular (and cerebrovascular) disease; the role of sleep periodic leg movements, sleep deprivation, and presence of common risk factors for heart disease in these patients remains to be determined. The aim of this study was to evaluate the eventual presence of risk factors for cerebrovascular disease in RLS. ⋯ Our findings argue against the presence of an altered lipid metabolism as a risk factor for the development of cerebrovascular disease in patients with RLS, even if they do support the idea that cerebrovascular disease might be frequent in this condition.
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Early administration of paracetamol may improve outcome of patients with acute stroke and a baseline body temperature of 37°C or above by lowering body temperature and preventing fever. Besides its antipyretic effects, paracetamol may affect blood pressure through cyclooxygenase-2 inhibition. We therefore aimed to assess the effect of high-dose paracetamol on blood pressure in patients with acute stroke. ⋯ High-dose paracetamol reduces not only body temperature but also systolic blood pressure in the first 12 h after start of treatment. Both effects may improve functional outcome after stroke, but this needs further study.
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The PFS-16 is a 16-item fatigue scale for Parkinson's disease (PD) developed in the UK. However, documented translations and psychometric evaluations are sparse. ⋯ These observations support the psychometric properties of the Swedish PFS-16, but cautions against dichotomised scoring.
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Acta Neurol. Scand. · Apr 2012
Animal model for sport-related concussion; ICP and cognitive function.
We have recently developed and characterized a rat model of mild traumatic brain injury which simulates the concussive injuries frequently encountered by players in American professional football. ⋯ Multiple impacts to the head raise intracranial pressure and impair cognitive function and exploratory activity in this animal model.
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Acta Neurol. Scand. · Mar 2012
Validation of the multiple sclerosis international quality of life (MusiQoL) questionnaire in Norwegian patients.
To assess the validity and reliability of the multidimensional, self-administered Multiple Sclerosis International Quality of Life (MusiQoL) questionnaire, previously validated in a large international sample, in Norwegian patients. ⋯ These results demonstrate that the Norwegian-language version of the MusiQoL questionnaire is a valid and reliable instrument for assessing health-related QoL in Norwegian patients with MS.