Acta neurologica Scandinavica
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Acta Neurol. Scand. · Nov 2020
Randomized Controlled Trial Multicenter StudyClinical outcomes and safety profile of Tenecteplase in wake-up stroke.
Tenecteplase has probably pharmacological and clinical advantages in the treatment of acute ischemic stroke. There are lacking data about safety and efficacy of tenecteplase in wake-up stroke (WUPS). ⋯ In WUPS patients treated in NOR-TEST, there was no difference in clinical outcomes at 90 days and no ICH events or deaths were observed in either alteplase- or tenecteplase-treated patients. Clinical Trial Registration-URL: https://www.clinicaltrials.gov. Unique identifier: NCT01949948.
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Acta Neurol. Scand. · May 2019
Multicenter Study Comparative StudyComparison of plasma and cerebrospinal fluid neurofilament light in a multiple sclerosis trial.
The main objective of this study was to evaluate the axonal component neurofilament light protein (NFL) in plasma and cerebrospinal fluid (CSF) as an outcome measure in a clinical trial on disease-modifying treatments in multiple sclerosis. ⋯ This study indicates that NFL in plasma is less sensitive as an endpoint in group comparisons than NFL in CSF. Given that plasma NFL is far easier to access, it is a promising and awaited method but further studies are needed to optimize the use in clinical trials.
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Acta Neurol. Scand. · Feb 2017
Multicenter StudyREM sleep behavior disorder and periodic leg movements during sleep in ALS.
To assess sleep characteristics and the occurrence of abnormal muscle activity during sleep, such as REM sleep without atonia (RSWA), REM sleep behavior disorder (RBD), and periodic leg movements during sleep (PLMS), in patients with amyotrophic lateral sclerosis (ALS). ⋯ Patients with ALS frequently present abnormalities of sleep that can be documented both at the clinical interview and at the polysomnographic evaluation, including insomnia, fragmented sleep, and increased PLMS. Moreover, abnormalities of REM sleep can be found in some of these patients.
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Acta Neurol. Scand. · Oct 2015
Randomized Controlled Trial Multicenter StudyGreater occipital nerve blockade for the treatment of chronic migraine: a randomized, multicenter, double-blind, and placebo-controlled study.
We aimed to assess the efficacy of greater occipital nerve (GON) blockade at chronic migraine (CM) treatment. ⋯ Our results suggest that GON blockade with bupivacaine was superior to placebo and was found to be effective, safe, and cost-effective for the treatment of CM. According to our knowledge, this is the first randomized, multicentre, double-blind, and placebo-controlled study in the literature in this field of work.
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Acta Neurol. Scand. · Jun 2014
Multicenter Study Clinical TrialEfficacy and tolerability of add-on lacosamide in children with Lennox-Gastaut syndrome.
Available data on the efficacy of lacosamide in children with Lennox-Gastaut syndrome (LGS) are scarce and controversial. We present our experience with lacosamide therapy in children affected by LGS. ⋯ A third of children with LGS were responders after lacosamide adjunctive therapy. Although caution is still necessary when the drug is used in children with LGS, our preliminary observations suggest that lacosamide might be effective and represent a possible therapeutic option in children affected by LGS.