Acta neurologica Scandinavica
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Acta Neurol. Scand. · Nov 1992
Randomized Controlled Trial Clinical TrialIntracutaneous sterile water injections do not relieve pain in cervicogenic headache.
Intracutaneous sterile water injections have been reported to relieve acute labor pain and cervical pain in whip-lash patients. A double blind cross-over trial has presently been conducted in 10 women with cervicogenic headache in order to investigate whether sterile water injections were effective in this disorder. No benefit was observed for either treatment (isotonic saline or sterile water), neither on pain during the first 14 days nor on neck mobility. We conclude that intracutaneous sterile water injections is not effective in cervicogenic headache.
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Acta Neurol. Scand. · Oct 1992
Randomized Controlled Trial Comparative Study Clinical TrialTreatment of myotonia with antiarrhythmic drugs.
The effects of disopyramide, phenytoin, mexiletine, and tocainide were compared in 30 patients with myotonic disorders. The severity of myotonia was assessed by clinical and electromyographic criteria at the end of each treatment phase lasting four weeks. ⋯ The benefits of myotonia control with pharmacological agents must be weight against the risk of therapy in the individual patient. Because of the risks of hematologic problems, TCD is not recommended by us for the treatment of myotonia.
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Acta Neurol. Scand. · Sep 1992
Six-year follow-up study on the efficacy and safety of vigabatrin in patients with epilepsy.
Twenty-five patients with epilepsy (mostly with partial seizures) who had responded favourably to a short-term trial of add-on vigabatrin entered maintenance treatment. After 52 to 78 months, 15 patients continue to take the drug with good therapeutic response. ⋯ In most patients, side effects were absent or mild, the most frequent complaint being weight gain. It is concluded that the antiepileptic efficacy and good clinical tolerability of vigabatrin are generally maintained during long-term treatment for up to 6 years.
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Acta Neurol. Scand. · Sep 1992
Case ReportsCarbamyl phosphate synthetase-1 deficiency discovered after valproic acid-induced coma.
Valproic acid induced coma is presented in an adult patient without a history of metabolic disease. Liver biopsy revealed a reduction in activity of carbamyl phosphate synthetase-I, an enzyme obligated for transformation of ammonia to urea in the urea cycle. After recovery CT scan follow-up showed marked cerebral atrophy which did not exist prior to the state of coma. Risk factors are discussed.
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Based on a case history of fetal haemorrhage due to maternal antiepileptic treatment and a review of 40 previously described similar cases, it is recommended that epileptic mothers receive vitamin K tablets throughout the month before delivery and intravenously during labour. It is further recommended that phytomenadione should be administered intravenously to the infant immediately after birth. ⋯ Alternatively, the drug treatment of women with epilepsy during pregnancy could be changed from liver enzyme inducing drugs to clonazepam, which is a benzodiazepine without liver enzyme-inducing properties. Further, no malformations have been reported in connection with this drug.