The Annals of pharmacotherapy
-
Letter Case Reports
Effect of dexamethasone on the decrease of serum phenytoin concentrations.
-
Case Reports
Gastrointestinal complications associated with intramuscular ketorolac tromethamine therapy in the elderly.
To report 3 cases of gastrointestinal (GI) complications associated with the use of intramuscular ketorolac tromethamine therapy in elderly patients. ⋯ We recommend that the manufacturer's guidelines be followed when ketorolac is used in elderly patients, and the drug should not be used in patients with a history of gastric ulcer disease. The use of misoprostol may be warranted as prophylactic therapy in high-risk patients who are receiving ketorolac.
-
Comparative Study
Estimating phenytoin concentrations by the Sheiner-Tozer method in adults with pronounced hypoalbuminemia.
To assess the performance of the Sheiner-Tozer equation when used to evaluate total phenytoin concentrations in patients with pronounced hypoalbuminemia. ⋯ The Sheiner-Tozer equation can normalize total phenytoin concentrations reliably in patients with low albumin concentrations at our institution.
-
To describe the use of continuous subcutaneous heparin infusion in the treatment of 2 cases of Trousseau's syndrome. ⋯ Continuous subcutaneous heparin infusion may be an effective option for the treatment of Trousseau's syndrome in the ambulatory setting.
-
Comparative Study
Quality assessment of economic evaluations in selected pharmacy, medical, and health economics journals.
To assess and compare the quality of economic studies in selected pharmacy, medical, and health economics journals. ⋯ Article quality for all journal types increased over time nonsignificantly; health economics journals scored highest, then medical journals, with pharmacy journals significantly lower (and having the highest standard deviation). We recommend that authors and reviewers pay closer attention to study perspective and ethical implications.