International archives of allergy and immunology
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Int. Arch. Allergy Immunol. · Jan 2021
Meta AnalysisCytokine Polymorphisms and Predisposition to Diabetic Nephropathy: A Meta-Analysis.
Cytokine polymorphismsmight influence the predisposition to diabetic nephropathy (DN), but the results of already published related studies are still controversial and ambiguous. ⋯ The meta-analysis results demonstrated that TNF-α -238 G/A, TNF-α -308 G/A, TNF-α -1031 C/T, IL-1A -889 C/T, IL-1B -511 C/Tand IL-18 -137 G/Cpolymorphisms might influence predisposition to DN in the overall pooled population. Moreover, TNF-α -308 G/A, IL-1B -511 C/T and IL-18 -137 G/C polymorphisms might influence predisposition to DN in Asians, whereas the IL-1B -511 C/T polymorphism might also influence predisposition to DN in Caucasians.
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Int. Arch. Allergy Immunol. · Jan 2021
Meta AnalysisDoes Asthma Increase the Mortality of Patients with COVID-19?: A Systematic Review and Meta-Analysis.
The purpose of this systematic review and meta-analysis was to explore the literature and collate data comparing the mortality of coronavirus disease 2019 (COVID-19) patients with and without asthma. The databases PubMed, Scopus, Embase, Google Scholar, and medRxiv.org were searched for studies comparing the clinical outcomes of asthmatic patients with those of nonasthmatic patients diagnosed with COVID-19. Mortality data were summarized using the Mantel-Haenszel OR with 95% CI in a random-effects model. ⋯ To conclude, preliminary data indicates that asthma as a comorbidity may not increase the mortality of COVID-19. Data on the influence of asthma on the risk of hospitalization, the duration of hospitalization, the requirement of ICU admission, and disease severity is still too limited to draw any strong conclusions. Further studies with a larger sample size are required to establish strong evidence.
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Int. Arch. Allergy Immunol. · Jan 2020
Meta AnalysisPredisposition to Hyperthyroidism May Be Influenced by Functional TNF-α, IL-1, IL-6, and IL-10 Polymorphisms: A Meta-Analysis.
Predisposition to hyperthyroidism may be influenced by functional gene polymorphisms in tumor necrosis factor-α (TNF-α), interleukin-1 (IL-1), interleukin-4 (IL-4), interleukin-6 (IL-6), and interleukin-10 (IL-10). However, the results of the studies published so far remain discrepant, so we conducted a meta-analysis to more robustly investigate relationships between TNF-α/IL-1/IL-4/IL-6/IL-10 polymorphisms and predisposition to hyperthyroidism. ⋯ This meta-analysis suggests that TNF-α -308 G/A, IL-1A -889 C/T, IL-1B -511 C/T, IL-6 -174 G/C, IL-6 -572 G/C, IL-10 -819 C/T, and IL-10 -1,082 A/G polymorphisms may influence predisposition to hyperthyroidism in certain ethnic groups.
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Int. Arch. Allergy Immunol. · Jan 2011
Review Meta AnalysisSystematic review on the efficacy of fexofenadine in seasonal allergic rhinitis: a meta-analysis of randomized, double-blind, placebo-controlled clinical trials.
Evidence-based medicine represents the effort to highlight the best intervention for patients, clinicians, and policy makers, each from their respective viewpoint, to solve a particular health condition. According to a recently diffused grading system of evidence and recommendations for medical interventions, efficacy and safety represent 2 of the most important features to consider, and data from meta-analyses of randomized controlled clinical trials (RCTs) is the strongest supporting demonstration. Fexofenadine has been used for its efficacy and safety in the treatment of allergic rhinitis (AR) for many years although no meta-analyses supporting its use currently exist. The aim of this study is to assess for the first time the efficacy and safety of fexofenadine in the treatment of AR by means of a meta-analytic analysis of existing RCTs. Since specific evidence should be provided to address recommendations in a pediatric population, the quality of the estimates of this subgroup analysis is assessed. ⋯ This study has 5 major strengths: it represents the first attempt to evaluate the efficacy and safety of fexofenadine in the treatment of AR by means of a meta-analysis of RCTs; there was consistency between positive results in terms of efficacy in TSS and in individual symptoms; a large population was studied; there was an irrelevant interstudy heterogeneity, and the AE frequency was similar in both groups. All of these values encourage the recommendation of fexofenadine for AR. Further research focused on the benefits and disadvantages for a pediatric population is needed.