Annals of internal medicine
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Comment Meta Analysis
Antihypertensive therapy reduced incident dementia vs. placebo at a median 4.3 y.
Peters R, Xu Y, Fitzgerald O, et al. Blood pressure lowering and prevention of dementia: an individual patient data meta-analysis. Eur Heart J. 2022;43:4980-90. 36282295.
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Review Meta Analysis
Vitamin D and Risk for Type 2 Diabetes in People With Prediabetes : A Systematic Review and Meta-analysis of Individual Participant Data From 3 Randomized Clinical Trials.
The role of vitamin D in people who are at risk for type 2 diabetes remains unclear. ⋯ None. (PROSPERO: CRD42020163522).
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Comment Meta Analysis
In adults receiving mechanical ventilation, selective decontamination of the digestive tract reduces hospital mortality.
Hammond NE, Myburgh J, Seppelt I, et al. Association between selective decontamination of the digestive tract and in-hospital mortality in intensive care unit patients receiving mechanical ventilation: a systematic review and meta-analysis. JAMA. 2022;328:1922-34. 36286098.
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Comment Meta Analysis
In AF, underdosing of DOACs was not linked to reduced bleeding.
Caso V, de Groot JR, Sanmartin Fernandez M, et al. Outcomes and drivers of inappropriate dosing of non-vitamin K antagonist oral anticoagulants (NOACs) in patients with atrial fibrillation: a systematic review and meta-analysis. Heart. 2023;109:178-85. 36316100.
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Primary care patients and clinicians may prefer alternative options to second-generation antidepressants for major depressive disorder (MDD). ⋯ American College of Physicians. (PROSPERO: CRD42020204703).