Annals of internal medicine
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Primary care patients and clinicians may prefer alternative options to second-generation antidepressants for major depressive disorder (MDD). ⋯ American College of Physicians. (PROSPERO: CRD42020204703).
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Comment Meta Analysis
Statins increase muscle pain or weakness at 1 y, with an absolute excess of 11 events/1000 person-y.
Cholesterol Treatment Trialists' Collaboration. Effect of statin therapy on muscle symptoms: an individual participant data meta-analysis of large-scale, randomised, double-blind trials. Lancet. 2022;400:832-45. 36049498.
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Meta Analysis
Anticoagulant Therapy for Cancer-Associated Thrombosis : A Cost-Effectiveness Analysis.
Direct oral anticoagulants (DOACs) offer an alternative to low-molecular-weight heparin (LMWH) and warfarin for treating cancer-associated thrombosis (CAT). ⋯ None.
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Comment Meta Analysis
In the general population, salt substitutes vs. regular salt reduce BP levels, CV outcomes, and mortality.
Yin X, Rodgers A, Perkovic A, et al. Effects of salt substitutes on clinical outcomes: a systematic review and meta-analysis. Heart. 2022;108:1608-15. 35945000.
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Comment Meta Analysis
In CV disease, clopidogrel reduces nonfatal MI and MACE vs. aspirin but not stroke or mortality.
Tasoudis PT, Kyriakoulis IG, Sagris D, et al. Clopidogrel monotherapy versus aspirin monotherapy in patients with established cardiovascular disease: systematic review and meta-analysis. Thromb Haemost. 2022;122:1879-87. 35577054.