Annals of internal medicine
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Randomized Controlled Trial Multicenter Study
Positron emission tomography in staging early lung cancer: a randomized trial.
Among patients with early-stage non-small cell lung cancer (NSCLC), preoperative imaging tests are important in defining surgical candidates. ⋯ Preoperative staging with PET-CT and cranial imaging identifies more patients with mediastinal and extrathoracic disease than conventional staging, thereby sparing more patients from stage-inappropriate surgery, but the strategy also incorrectly upstaged disease in more patients.
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Randomized Controlled Trial Multicenter Study Comparative Study
Comparison of Tripterygium wilfordii Hook F versus sulfasalazine in the treatment of rheumatoid arthritis: a randomized trial.
Extracts of the medicinal plant Tripterygium wilfordii Hook F (TwHF) have been used in China for centuries to treat a spectrum of inflammatory diseases. ⋯ In patients who continued treatment for 24 weeks and could also use stable oral prednisone and nonsteroidal anti-inflammatory drugs, attainment of the ACR 20 response criteria was significantly greater with TwHF extract than with sulfasalazine.
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Randomized Controlled Trial Multicenter Study
Internet-based self-management plus education compared with usual care in asthma: a randomized trial.
The Internet may support patient self-management of chronic conditions, such as asthma. ⋯ Netherlands Organization for Health Research and Development, ZonMw, and Netherlands Asthma Foundation.
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Multicenter Study
Failure to recognize newly identified aortic dilations in a health care system with an advanced electronic medical record.
Concern is growing about missed test results, but data assessing their effect on patient safety are limited. ⋯ Clinicians neglect to note a substantial proportion of new aortic dilations in the EMR. The findings highlight the need for better strategies to ensure documentation of follow-up of tests.
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Randomized Controlled Trial Multicenter Study
Stent placement in patients with atherosclerotic renal artery stenosis and impaired renal function: a randomized trial.
Little is known about the efficacy and safety of renal artery stenting in patients with atherosclerotic renal artery stenosis (ARAS) and impaired renal function. ⋯ Stent placement with medical treatment had no clear effect on progression of impaired renal function but led to a small number of significant procedure-related complications. The study findings favor a conservative approach to patients with ARAS, focused on cardiovascular risk factor management and avoiding stenting.