Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals
-
Chromogranin A (CgA) is a novel biomarker with potential to assess mortality risk of patients with severe sepsis. ⋯ High CgA levels predict ICU mortality in severely septic patients without prior cardiovascular disease.
-
To test the hypothesis whether serum advanced oxidation protein products (AOPP) are associated with increased acute kidney injury (AKI) after cardiopulmonary bypass (CPB) and could serve as a biomarker in this aspect, we performed a prospective cohort study. Thirty-five (22.3%) patients developed AKI, and 32 age- and gender-matched patients without AKI were selected as control. ⋯ An optimal serum AOPP 1 h after CPB cutoff of 69.9 μmol/L had a sensitivity of 74%, specificity of 63% and a positive predictive value of 68% for predicting AKI. These results demonstrated that serum AOPP might be an early biomarker for AKI after CPB.
-
Comparative Study
Mortality prediction by acute kidney injury biomarkers in comparison with serum creatinine.
To investigate the performance of acute kidney injury (AKI) biomarkers for mortality prediction. ⋯ These AKI biomarkers can specifically detect high-risk patients among creatinine-base diagnosed AKI.
-
Chronic obstructive pulmonary disease (COPD) develops only in smoking-sensitive smokers and manifests heterogeneous phenotypes, including emphysema and non-emphysema types. We aimed to identify biomarkers related to the smoking-sensitivity and phenotypes of COPD. ⋯ Plasma concentrations of 33 inflammatory markers were measured in four groups as well as Non-smokers using multiplex protein arrays. IL-5, IL-7 and IL-13 were identified to be associated with smoking sensitivity and IL-6 and IL-10 were candidate biomarkers for airway-lesion dominant COPD.
-
Ceramide causes endothelial apoptosis and emphysema-like changes in animal models. ⋯ Higher plasma levels of sphingomyelin predicted greater annual increase in quantitatively measured percent emphysema.