Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
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J Coll Physicians Surg Pak · Nov 2022
Virtual Conference Cannot Replace Physical Meeting: Lessons from COVID-19 Pandemic Online Transformation.
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J Coll Physicians Surg Pak · Nov 2022
Case ReportsConcomitant Use of Ado-trastuzumab Emtansine and Imatinib in a Patient of CML and Metastatic Breast Cancer.
Imatinib is a CYP3A4 inhibitor, while ado-trastuzumab is a CYP3A4 substrate. Imatinib can interact with ado-trastuzumab emtansine (T-DM1) and can increase T-DM1 concentrations, leading to T-DM1-related toxicity. There is no trial or case report in the literature on the concomitant use of Imatinib and T-DM1. ⋯ No side effects were observed except for grade 1 fatigue. This case report is the first to report the concomitant use of T-DM1 and imatinib in a patient of CML and metastatic breast cancer. Key Words: Imatinib, Ado-trastuzumab emtansine, Breast cancer, Chronic myeloid leukaemia.
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J Coll Physicians Surg Pak · Nov 2022
Observational StudyEvaluation of mTOR Activity in COPD Patients with Emphysema.
To evaluate the function of the mammalian target of the rapamycin (mTOR) pathway in chronic obstructive pulmonary disease (COPD) patients with emphysema. ⋯ COPD, Emphysema, mTOR.
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J Coll Physicians Surg Pak · Nov 2022
Relationship between the Volume Ratio of Subchorionic Hematoma to Gestation SAC in First-trimester and Pregnancy Outcome of Patients with Threatened Abortion.
To find the relationship between the volume ratio of subchorionic hematoma (SCH) to gestation sac measured by three-dimensional ultrasound and pregnancy outcome of patients with threatened abortion. ⋯ Ultrasonography, Hematoma, Pregnancy outcome, Threatened abortion, ROC curve.