Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
-
J Coll Physicians Surg Pak · Nov 2022
Case ReportsConcomitant Use of Ado-trastuzumab Emtansine and Imatinib in a Patient of CML and Metastatic Breast Cancer.
Imatinib is a CYP3A4 inhibitor, while ado-trastuzumab is a CYP3A4 substrate. Imatinib can interact with ado-trastuzumab emtansine (T-DM1) and can increase T-DM1 concentrations, leading to T-DM1-related toxicity. There is no trial or case report in the literature on the concomitant use of Imatinib and T-DM1. ⋯ No side effects were observed except for grade 1 fatigue. This case report is the first to report the concomitant use of T-DM1 and imatinib in a patient of CML and metastatic breast cancer. Key Words: Imatinib, Ado-trastuzumab emtansine, Breast cancer, Chronic myeloid leukaemia.
-
J Coll Physicians Surg Pak · Nov 2022
Observational StudyEvaluation of mTOR Activity in COPD Patients with Emphysema.
To evaluate the function of the mammalian target of the rapamycin (mTOR) pathway in chronic obstructive pulmonary disease (COPD) patients with emphysema. ⋯ COPD, Emphysema, mTOR.
-
J Coll Physicians Surg Pak · Nov 2022
Fibrinogen Levels and Total Serum Bile Acids in Intrahepatic Cholestasis of Pregnancy.
To determine the role of complete blood count and coagulation function factors as inflammatory markers in intrahepatic cholestasis of pregnancy (ICP). ⋯ Bile acids, Cholestasis, Coagulation function parameters, Fibrinogen levels, Inflammation.
-
J Coll Physicians Surg Pak · Nov 2022
Relationship between the Volume Ratio of Subchorionic Hematoma to Gestation SAC in First-trimester and Pregnancy Outcome of Patients with Threatened Abortion.
To find the relationship between the volume ratio of subchorionic hematoma (SCH) to gestation sac measured by three-dimensional ultrasound and pregnancy outcome of patients with threatened abortion. ⋯ Ultrasonography, Hematoma, Pregnancy outcome, Threatened abortion, ROC curve.
-
J Coll Physicians Surg Pak · Nov 2022
Case ReportsTakotsubo Like Cardiomyopathy with Concomitant Pheochromocytoma: A Rare Presentation.
Pheochromocytoma classically presents with headache, diaphoresis, palpitations and, raised blood pressure. Rarely, it manifests as cardiomyopathy. Herein, we present a case of a 42-year woman who presented with heart failure and on work-up was found to have pheochromocytoma leading to Takotsubo-like cardiomyopathy. ⋯ Within two weeks of presentation and before surgical excision of the mass, she recovered from cardiomyopathy. After medical optimisation, the patient underwent elective adrenalectomy, which on histological evaluation revealed pheochromocytoma. Key Words: Cardiomyopathy, Pheochromocytoma, Adrenal mass.