Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
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J Coll Physicians Surg Pak · Sep 2022
Clinical Significance of Expression of Periostin in Non-small Cell Lung Cancer.
To analyse the expression of serum periostin in patients with non-small cell lung cancer (NSCLC) and its clinical significance. ⋯ Non-small cell lung cancer, Periostin expression, Clinical significance.
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J Coll Physicians Surg Pak · Sep 2022
Safety and Efficacy of Zoledronic Acid in children with Osteogenesis Imperfecta.
To evaluate the efficacy and safety of zoledronic acid in children with osteogenesis imperfecta (OI). ⋯ Osteogenesis imperfecta (OI), Bisphosphonates (BPs), DEXA scan, Bone mineral density (BMD).
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J Coll Physicians Surg Pak · Sep 2022
Comparison of Low Molecular Weight Heparin Used alone or Combined with Aspirin in the Treatment of Fetal Growth Restriction.
The objective of the study was to compare the efficacy of low-molecular weight heparin (LMWH) alone and use in the combination with aspirin in the treatment of fetal growth restriction (FGR) patients. Ninety-six FGR patients were divided into the LMWH group (n=48) and the combined group (n=48), according to the different treatments. ⋯ Combination of LMWH with aspirin in FGR patients effectively reduced levels of IL-6 and TNF-α within the mother, improved fetal developmental parameters, and reduced the frequency of pregnancy complications and adverse neonatal outcomes compared with LMWH treatment alone. Key Words: Fetal growth restriction (FGR), Low-molecular weight heparin (LMWH), Aspirin, Pregnancy, Newborn.
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J Coll Physicians Surg Pak · Sep 2022
Case ReportsEpithelioid Inflammatory Myofibroblastic Sarcoma with Leukemoid Reaction.
Epithelioid inflammatory myofibroblastic sarcoma (EIMS) is a rare and aggressive inflammatory myofibroblastic tumour (IMT) variant. This report identifies the first case of EIMS with leukemoid reaction. This is also the first case in which pancreatic infiltration occurred from the disease onset. ⋯ There is no consensus on the treatment of EIMS. Since ALK rearrangement presents in all the EIMS cases, surgical resection combined with crizotinib or other targeted drugs may improve the prognosis. Key Words: Sarcoma, Soft tissue neoplasms, Leukemoid reaction, Crizotinib.