Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
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J Coll Physicians Surg Pak · Feb 2020
Inadvertent Perioperative Hypothermia and Important Risk Factors during Major Abdominal Surgeries.
A relation between inadvertent perioperative hypothermia and possible important risk factors during major abdominal surgeries was investigated. ⋯ In this study, important risk factors for inadvertent hypothermia were found as; male gender, advanced age, high ASA scores, smoking, prolonged duration of operation, transfusion of fluids and/or PRBCs.
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J Coll Physicians Surg Pak · Feb 2020
Comparative StudyElevated Tumor Necrosis Factor (TNF)-α mRNA Expression Correlates with Nuclear Factor Kappa B Expression in Peripheral Blood Mononuclear Cells in Preeclampsia.
To evaluate, compare and correlate the mRNA expression of nuclear factor kappa B (NF-kB) and tumor necrosis factor alpha (TNF-α) in peripheral blood mononuclear cells in preeclampsia and normotensive group. ⋯ The peripheral blood mononuclear cells mRNA expression of NF-kB and TNF-α differed within the two groups with an increase in expression in the diseased group (p <0.001). There was an increase of 2.79 fold in mRNA expression of TNF-α while the result for NF-αB was 2.28 fold. The difference in the expression of both NF-kB and TNF-α was significant within the two subgroups of preeclampsia (p <0.001). TNF-α was found to be strongly correlated with NF-kB (p <0.01).
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J Coll Physicians Surg Pak · Feb 2020
Supervisor's Feedback on Progress of E-Logbook System of CPSP: A Cross-sectional Survey.
To determine the feedback of supervisors regarding role of e-logbook in monitoring of training, strengthening supervisor-supervisee relationship and improving overall environment of postgraduate training at College of Physicians and Surgeons Pakistan (CPSP). ⋯ Supervisors perceive electronic logbooks as a useful medium for training monitoring and improvement of the relationship between supervisors and their residents. They have shown wide acceptability to the e-log system. E-log should continue as the primary monitoring system of the training programmes of CPSP.
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J Coll Physicians Surg Pak · Feb 2020
Case ReportsHereditary Spherocytosis Associated with Gilbert Syndrome Diagnosed with Liver Biopsy Examination and Exome Sequencing.
Depending on which part of the physiological pathway is affected by the pathology, jaundice is classified into three categories: pre-hepatic/hemolytic, hepatic/hepatocellular, and post-hepatic/cholestatic. With routine laboratory tests, most cases of jaundice can be etiologically diagnosed. However, exceptions do occur. ⋯ Her laboratory tests showed a moderate impairment of liver function and a positive osmotic fragility test. Computed tomography scan of her upper abdomen revealed multiple gallbladder stones and splenomegaly. With the help of liver pathological examination and exome sequencing, this patient was finally diagnosed as hereditary spherocytosis combined with Gilbert syndrome.
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J Coll Physicians Surg Pak · Feb 2020
Diagnostic Value of Serum Biomarkers for Patients Undergoing Curative Resection with Non-B, Non-C Hepatocellular Carcinoma.
To determine the diagnostic value of alpha-fetoprotein (AFP) and des-gamma-carboxy prothrombin (DCP) for patients with non-B, non-C hepatocellular carcinoma (NBNC HCC). ⋯ A combination of AFP and DCP is useful for assisting the diagnosis of NBNC HCC before surgery. AFP and DCP showed better diagnostic accuracy for HBcAb-negativity compared with HBcAb-positivity in NBNC HCC patients.