The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
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Int. J. Tuberc. Lung Dis. · Jul 2011
Reliability and validity of the St George's Respiratory Questionnaire for asthma.
The St George's Respiratory Questionnaire (SGRQ) is a self-administered questionnaire that has been used to evaluate the health-related quality of life of patients with chronic respiratory diseases. ⋯ With the exception of the SGRQ-K symptoms, SGRQ-K is a reliable and valid test for evaluation of the quality of life of patients with asthma. Scores were well correlated with duration of symptoms, lung function and previous history of asthma exacerbation.
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Int. J. Tuberc. Lung Dis. · Jun 2011
Randomized Controlled Trial Multicenter StudyResults at 30 months of a randomised trial of two 8-month regimens for the treatment of tuberculosis.
An 8-month isoniazid (INH, H) and ethambutol (EMB, E) based regimen recommended by the World Health Organization (WHO) had never been evaluated in a randomised controlled multicentre trial. ⋯ These results confirm earlier findings demonstrating the inferiority of the INH+EMB-based regimens to the standard 6-month regimen. The WHO has withdrawn its recommendation of these regimens.
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Int. J. Tuberc. Lung Dis. · Jun 2011
Randomized Controlled TrialRisk of tuberculosis among contacts of isoniazid-resistant and isoniazid-susceptible cases.
To compare the risk to household contacts of isoniazid (INH) susceptible and INH-resistant cases of tuberculosis (TB) in a rural community in South India. ⋯ The baseline prevalence of tuberculous infection was substantially higher in contacts of INH-resistant than INH-susceptible patients, but the incidence of tuberculous disease over a 15-year follow-up was similar in the two series, and twice as high as in non-contacts.
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Int. J. Tuberc. Lung Dis. · May 2011
The functioning of oxygen concentrators in resource-limited settings: a situation assessment in two countries.
The paediatric wards of hospitals in Malawi and Mongolia. ⋯ Years after installation of oxygen concentrators, many machines were still functioning, indicating that widespread use can be sustained in resource-limited settings. However, concentrator performance varied substantially. Procurement of high-quality and appropriate equipment is critical, and resources should be made available for ongoing maintenance.
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Int. J. Tuberc. Lung Dis. · May 2011
Review Meta AnalysisInterleukin-10 polymorphisms and tuberculosis susceptibility: a meta-analysis.
A large number of studies have shown that polymorphisms in the interleukin 10 (IL-10) gene are implicated in susceptibility to tuberculosis (TB). However, the results are inconsistent and inconclusive. ⋯ This meta-analysis suggests that the -1082G/A polymorphism of the IL-10 gene could be a risk factor for TB in Europeans. Further studies with larger populations are required to assess the association between IL-10 polymorphisms and TB susceptibility.