Neuromodulation : journal of the International Neuromodulation Society
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Randomized Controlled Trial
Functional electrical stimulation with exercises for standing balance and weight transfer in acute stroke patients: a feasibility randomized controlled trial.
To test parameters needed for the design of a larger trial including the following: 1) identifying eligible participants, recruitment, and retention rates; 2) the feasibility and acceptability of delivering functional electrical stimulation (FES) to the gluteus maximus and quadriceps femoris for acute stroke patients in a hospital rehabilitation setting; 3) the outcome measures; 4) obtaining initial estimates of effect size; and 5) clarifying the relevant control group. ⋯ FES is feasible in this patient group but further feasibility and definitive trials are required.
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Randomized Controlled Trial Multicenter Study
Spinal cord stimulation therapy for patients with refractory angina who are not candidates for revascularization.
The aim of this study was to evaluate the safety and efficacy of spinal cord stimulation (SCS) for refractory angina. ⋯ Although this study was terminated early, the results obtained at six months suggest that SCS (HS) is not more effective than the control (LS) in patients with refractory angina.
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Randomized Controlled Trial
Temporal profile of functional visual rehabilitative outcomes modulated by transcranial direct current stimulation.
We have previously reported that transcranial direct current stimulation (tDCS) delivered to the occipital cortex enhances visual functional recovery when combined with three months of computer-based rehabilitative training in patients with hemianopia. The principal objective of this study was to evaluate the temporal sequence of effects of tDCS on visual recovery as they appear over the course of training and across different indicators of visual function. ⋯ These results suggest that tDCS may differentially affect the magnitude and sequence of visual recovery in a manner that is task specific to the type of visual rehabilitative training strategy employed.
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Randomized Controlled Trial Comparative Study
A comparison of the hypoalgesic effects of transcutaneous electrical nerve stimulation (TENS) and non-invasive interactive neurostimulation (InterX(®)) on experimentally induced blunt pressure pain using healthy human volunteers.
Non-invasive interactive neurostimulation (InterX(®)) delivers high amplitude electrical pulsed currents at points of low impedance on the skin. This study compared the hypoalgesic effect of non-invasive interactive neurostimulation with transcutaneous electrical nerve stimulation (TENS). ⋯ Given the limited power of this study, we show that there were no significant differences in hypoalgesia between non-invasive interactive neurostimulation and TENS. Unlike our previous studies we also failed to detect a change pain threshold during TENS. Nevertheless, our findings can be used to inform the design of an appropriately powered study on pain patients.
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Case Reports Randomized Controlled Trial
Deep brain stimulation for early-stage Parkinson's disease: an illustrative case.
Subthalamic nucleus (STN) deep brain stimulation (DBS) is an effective intervention in advanced Parkinson's disease (PD), but its efficacy and safety in early PD are unknown. We are conducting a randomized pilot trial investigating DBS in early PD. This report describes one participant who received bilateral STN-DBS. ⋯ This report details the first successful application of bilateral STN-DBS for early-stage PD during a clinical trial.