World Neurosurg
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Intervertebral disc degeneration (IVDD) is a common cause of lower back pain, and cell apoptosis plays a key role in its progression. This study explores the therapeutic potential of a reactive oxygen species (ROS)-responsive hydrogel loaded with allicin for treating IVDD. ⋯ ROS-responsive hydrogel loaded with allicin shows potential as a therapeutic approach for IVDD by inhibiting cell apoptosis and reducing disc degeneration in vivo.
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There is a dearth of literature regarding prognostic and predictive factors for outcome following pediatric decompressive craniectomy (DC) performed after traumatic brain injury (TBI). The aim of this study was to develop a random forest machine learning algorithm to predict outcomes following DC in pediatric patients. ⋯ CRF and SRF models successfully predicted 6-month outcomes and mortality following DC in pediatric patients with TBI. These results suggest that random forest models may be efficacious for predicting outcome in this patient population.
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Endovascular thrombectomy (EVT) is recommended for acute ischemic stroke due to large-vessel occlusion. However, approximately 50% of patients still experience poor outcomes after the procedure. This study aimed to assess whether a nomogram model that integrates computed tomography angiography radiomics features and clinical variables can predict EVT outcomes in patients with acute ischemic stroke. ⋯ Combining a radiomics nomogram with clinical predictors could effectively forecast EVT outcomes in patients with acute anterior circulation large vessel occlusion stroke.
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This study aimed to investigate the immunologic profile of chronic subdural hematoma (CSDH) subtypes based on their radiologic appearances, with a focus on comparing the membranous CSDH to other subtypes. ⋯ This study demonstrates that CSDH subtypes, particularly the "Membranous" subtype, possess a distinct immunologic profile. These findings provide novel insights into CSDH pathophysiology. The unique inflammatory landscape of "Membranous" CSDH, marked by elevated matrix metallopeptidase 9 and IL-8 levels, may contribute to its chronic nature.
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This study explores the vital elements of patient satisfaction in hospital settings, with an emphasis on the aspects of service quality and patient-hospital interaction. It looks at how patients perceive several aspects of service quality, such as assurance, tangibility, empathy, responsiveness, and consistency. ⋯ The study emphasizes the value of excellent patient-hospital interactions and the importance of communication, empathy, and trust-building in promoting these outcomes.