The Journal of clinical endocrinology and metabolism
The most recent articles from:
February 2011
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J. Clin. Endocrinol. Metab. · Feb 2011
Randomized Controlled Trial Multicenter StudyAlendronate for the treatment of pediatric osteogenesis imperfecta: a randomized placebo-controlled study.
Information on the use of oral bisphosphonate agents to treat pediatric osteogenesis imperfecta (OI) is limited. ⋯ Oral ALN for 2 yr in pediatric patients with OI significantly decreased bone turnover and increased spine areal BMD but was not associated with improved fracture outcomes.
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J. Clin. Endocrinol. Metab. · Feb 2011
Multicenter StudyEffect of denosumab on bone mineral density and biochemical markers of bone turnover: six-year results of a phase 2 clinical trial.
This is a study extension to evaluate the efficacy and safety of long-term treatment with denosumab in postmenopausal women with low bone mass. ⋯ In this study, denosumab was well tolerated and effective through 6 yr of continuous treatment in postmenopausal women with low bone mass.