Int J Clin Pharm Th
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Int J Clin Pharm Th · Jan 2015
Case ReportsFirst case report of suspected onset of convulsive seizures due to co-administration of valproic acid and tebipenem.
A patient presented with convulsive seizures when sodium valproate (VPA) and tebipenem pivoxil (Orapenem) were co-administered accidentally. The seizures were suspected to be caused by a reduced concentration of VPA in the blood. ⋯ The results suggest that co-administration of oral carbapenem antibiotics and VPA should be avoided.
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Int J Clin Pharm Th · Dec 2014
Randomized Controlled TrialEffects of postoperative analgesia with the combination of tramadol and lornoxicam on serum inflammatory cytokines in patients with gastric cancer.
To compare the effects of postoperative patient-controlled intravenous analgesia (PCIA) with morphine, tramadol, or tramadol combined with lornoxicam on serum inflammatory cytokine production. ⋯ PCIA using tramadol combined with lornoxicam has less influence on inflammatory cytokines than morphine or tramadol alone in patients undergoing gastric cancer surgery.
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Int J Clin Pharm Th · Sep 2014
Randomized Controlled Trial Comparative StudyA randomized study of intranasal vs. intravenous infusion of dexmedetomidine in gastroscopy.
To compare the respiratory and circulatory parameters between intranasal and intravenous dexmedetomidine in gastroscopy. ⋯ Intranasal dexmedetomidine is a new, safe, and effective approach for gastroscopy because it has more stable respiratory and circulatory parameters and less adverse reactions than intravenous dexmedetomidine.
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Int J Clin Pharm Th · Sep 2014
Evaluation of etanercept dose reduction in patients with rheumatoid arthritis using pharmacokinetic/pharmacodynamic modeling and simulation.
In this study, we attempt to explore the feasibility of alternative dosing regimens of etanercept in patients with rheumatoid arthritis (RA) using pharmacokinetic/pharmacodynamic (PK/PD) modeling and simulation. ⋯ In this study, the clinical data was well described by the models developed, and several alternative dosing regimens were proposed. Further clinical studies in patients are still needed to confirm our findings.