Arch Neurol Chicago
-
Arch Neurol Chicago · Jan 2005
Randomized Controlled Trial Comparative Study Clinical TrialIntermittent prednisone therapy in Duchenne muscular dystrophy: a randomized controlled trial.
Prednisone treatment is used to prolong ambulation in patients with Duchenne muscular dystrophy (DMD). However, since severe adverse effects often accompany prednisone treatment, it is debatable whether the benefits of prednisone treatment outweigh its adverse effects. ⋯ Prednisone slowed deterioration of muscle function and muscle force in ambulant patients with DMD. Although adverse effects were present, patient quality of life was not affected. Therefore, short-term prednisone treatment can be recommended to preserve motor functions in ambulant patients with DMD.
-
Arch Neurol Chicago · Jan 2005
Case Reports Comparative StudyStimulation of the subthalamic nucleus in a patient with Parkinson disease and essential tremor.
The preferred surgical target for the treatment of Parkinson disease (PD) is either the internal globus pallidus or the subthalamic nucleus (STN); the target for treatment of essential tremor (ET) is the thalamic subnucleus ventralis intermedius (Vim). Some patients with PD have coexistent ET, and the identification of a single surgical target to treat both parkinsonian motor symptoms and ET would be of practical importance. ⋯ Placement of an STN DBS should be considered as the procedure of choice for surgical treatment of patients with a combination of PD and ET.