Arch Neurol Chicago
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Arch Neurol Chicago · Jan 2005
Randomized Controlled Trial Comparative Study Clinical TrialIntermittent prednisone therapy in Duchenne muscular dystrophy: a randomized controlled trial.
Prednisone treatment is used to prolong ambulation in patients with Duchenne muscular dystrophy (DMD). However, since severe adverse effects often accompany prednisone treatment, it is debatable whether the benefits of prednisone treatment outweigh its adverse effects. ⋯ Prednisone slowed deterioration of muscle function and muscle force in ambulant patients with DMD. Although adverse effects were present, patient quality of life was not affected. Therefore, short-term prednisone treatment can be recommended to preserve motor functions in ambulant patients with DMD.