Saudi Med J
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To ascertain the prevalence of depressive symptoms and identify related risk factors among adolescents. ⋯ This study reveals the increased prevalence of depressive symptoms in adolescents and highlights the complex interplay of demographic, behavioral, and social determinants. Findings emphasize the necessity for targeted, evidence-based interventions to enhance adolescent mental health.
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To review the outcomes of the cochlear implantation program at King Abdallah Medical Center (KAMC) in Makkah from its launch in 2018 to 2023, focusing on patient demographics, procedural details, and complications. ⋯ The CI program at KAMC has demonstrated to be a safe and effective approach for treating severe-to-profound hearing loss. Minor complications were observed, and follow-up adherence was strong. The study emphasizes the importance of ongoing accreditation and support for the program to ensure its success in hearing rehabilitation.
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Observational Study
Concordance between homeostatic model assessment and triglyceride glucose index in assessing insulin resistance among HIV-infected patients.
To evaluate the concordance between the triglyceride glucose (TyG) index and the homeostatic model assessment of insulin resistance (HOMA-IR) in assessing insulin resistance (IR) in people living with HIV (PLWH). Additionally, we aimed to estimate a cut-off value for the TyG index in PLWH. ⋯ Our study identified correlation between the TyG index and HOMA IR index in PLWH. The TyG index may serve as an effective alternative to HOMA-IR for evaluating insulin resistance in PLWH.".
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To identify genetic polymorphisms in factor I fibrinogen (rs6050) and factor XI plasma thromboplastin (rs4253417) in Saudi women with recurrent spontaneous miscarriage (RSM). Furthermore, to compare the levels of clotting factors in the blood of patients and healthy controls. ⋯ We demonstrated a significant correlation between genetic polymorphisms in factor I fibrinogen in certain genes studied and RSM. This association could be attributed to changes in fibrinogen levels, which impact the coagulation process and lead to an increase in thrombotic events, which are recognized as risk factors for miscarriage. Notably, variations in the other genes examined did not exhibit any association with the risk of RSM.
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To characterize the potential role of Y-chromosome microdeletion (YCM) as a genetic cause for infertility in the Arab population from the Al Madinah Al Munawarah. ⋯ Our findings for prevalence in Arab population of Al Madinah Al Munawarah is comparable to other studies from Saudi Arabia. However, large variance in the prevalence of YCM in the Arab population of other Middle Eastern countries is reportedly observed. The YCM has significant prognostic value, since it indicates the spermatogenic profile, the success probability of assisted reproduction technique (ART) procedures as testicular sperm extraction and apprise of potential risk of vertical transmission of microdeletion from father to son in patients opting for ART. With these considerations, we re-emphasize the need for genetic screening of YCM in azoo- and oligozoospermic infertile men.