Scand J Urol Nephrol
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Scand J Urol Nephrol · Aug 1997
Case ReportsEntrapment neuropathy of the internal pudendal nerve. Report of two cases.
Entrapment neuropathy of the internal pudendal nerve in the Alcock canal is a rare entity and literature on the subject is lacking. The pathogenesis of this disease is probably related to repeated microtraumatisms of the perineal region acting on the Alcock canal or dysmetabolic diseases favouring compression of the pudendal nerve inside the Alcock canal. In this article two new cases which have come to our attention are described and literature on the topic, with special regard to diagnosis and treatment, is reviewed.
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Scand J Urol Nephrol · Jun 1997
Case ReportsSimultaneous Wilms' tumours in monozygotic twins. Case report and review of the literature.
Familial cases of Wilms' tumour indicate that some of these tumours have a genetic origin. However, the role of constitutional genetic and shared environmental factors in the causation of these tumours, is not well understood. We have observed the very rare occurrence of simultaneous Wilms' tumour in monozygotic twins; one of them with a bilateral tumour and fatal outcome at 18 months of age. The other was in good health at the age of 24 years.
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Scand J Urol Nephrol · Dec 1996
Case ReportsProgression from adenocarcinoma to small cell carcinoma of the prostate with normalization of prostate-specific antigen (PSA) levels.
We report a case of prostatic cancer in which transformation from adenocarcinoma into small cell carcinoma was demonstrated both by histology and immunohistochemistry. This phenomenon supports the hypothesis that small cell carcinoma of the prostate originates from multipotential prostatic epithelial cells.
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We describe the clinical and pathological findings in two Japanese men with small cell carcinoma of the prostate; case 1 was 58 years old and case 2 was 24 years old. Case 1 was initially diagnosed as a poorly differentiated adenocarcinoma of the prostate, stage D2, with marked elevation of serum neuron-specific enolase (NSE), carcinoembryonic antigen (CEA), and CA 19-9 levels. The patient had undergone castration and systemic chemotherapy. ⋯ CEA was intensely positive in the tumour lesions from case 1, and NSE and ACTH were focally positive, and calcitonin, serotonin, CA 19-9, and PSA were weakly positive only in several cells in the tumour lesions from case 1. In the tumour lesion from case 2, NSE was intensely positive, and chromogranin A was weakly positive. These findings support the neuroendocrine nature of this neoplasm.