Polskie Archiwum Medycyny Wewnętrznej
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Pol. Arch. Med. Wewn.
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Pol. Arch. Med. Wewn. · Nov 2022
Clinical insights into the role of immunosuppression and its disturbances in solid organ transplant recipients with coronavirus disease 2019.
The COVID-19 pandemic has disproportionately affected patients who have undergone solid organ transplantation (SOT). ⋯ In our study, kidney transplant recipients showed significant disturbances of tacrolimus metabolism, which may account for kidney function worsening during COVID‑19. Moreover, infection was more common in patients with recent kidney or heart transplant, which suggests that the level of immunosuppression may affect morbidity related to SARS‑CoV‑2 infection.