Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases
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Zhonghua Jie He He Hu Xi Za Zhi · Jan 2012
[Changes of CD(4)(+)Foxp3(+) regulatory T cells and CD(4)(+)IL-17(+)T cells in cigarette smoke-exposed rats].
To evaluate the changes of CD(4)(+)IL-17(+) T (Th17) and CD(4)(+)Foxp3(+) regulatory T (Treg) cells in peripheral blood and bronchoalveolar lavage fluid (BALF), and therefore to explore the role of Th17 and Treg in cigarette smoke-induced airway inflammation/COPD in rats. ⋯ An elevated expression of Th17 and Treg cells and an increase of inflammatory cytokines were evident in airway inflammation of cigarette smoke-exposed rats, suggesting that Treg was involved in the immunological regulation and Th17 was associated with the persistent inflammation in cigarette smoke-induced airway inflammation in rats.
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Zhonghua Jie He He Hu Xi Za Zhi · Dec 2011
[The relationship between inflammatory mediators and pulmonary hypertension in patients with chronic obstructive pulmonary disease].
The levels of C-reactive protein (CRP), tumor necrosis factor (TNF)-α, brain natriuretic peptide (BNP) and endothelin-1 (ET-1) were investigated to analyze the systemic inflammation in chronic obstructive pulmonary disease (COPD) patients with and without pulmonary hypertension. ⋯ The level of CRP, ET-1 and BNP were related to pulmonary hypertension in COPD patients, suggesting that systemic inflammation play a role in the pathogenesis of pulmonary hypertension in COPD.
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Zhonghua Jie He He Hu Xi Za Zhi · Nov 2011
[The effects of a domestically made jet ventilator in dogs during interventional procedures by rigid bronchoscopy under general anesthesia].
To observe the effects of a domestically made jet ventilator in dogs during interventional procedures by rigid bronchoscopy under general anesthesia. ⋯ This domestically made jet ventilator could not provide enough effective ventilation during interventional procedures with rigid bronchoscopy under general anesthesia because hypoxemia and hypercapnia occurred when the operation time was prolonged. The PaO(2) and PaCO(2) of the dogs were better when spontaneous breathing was maintained during the procedure. The ventilation effects of the jet ventilator was closely related with its driving pressure. The oxygen concentration at the distal end of the rigid bronchoscope was lower than 40% in most situation when it was in the midrange (3 - 6 centimeters in the adapter) under high pressure oxygen (FiO(2) 100%). There was no significant change in the oxygen concentration with adjustment of the driving pressure or the I:E ratio of the jet ventilator.
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Zhonghua Jie He He Hu Xi Za Zhi · Oct 2011
[Interventional bronchoscopy with the use of mechanical ventilation by larynx mask or tracheal intubation under general anesthesia].
To explore and evaluate the technique of performing interventional bronchoscopy by using mechanical ventilation with larynx mask or tracheal intubation under general anesthesia. ⋯ Interventional bronchoscopy by using mechanical ventilation with larynx mask or tracheal intubation under general anesthesia was safe and reliable. Although peak airway pressure increased following insertion of bronchoscope, the mean airway pressure was maintained in a low level. When performing interventional bronchoscopy during mechanical ventilation, the inside diameter of larynx mask and tracheal intubation should be as large as possible to minimize airway pressure and auto-PEEP.
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Zhonghua Jie He He Hu Xi Za Zhi · Oct 2011
[Effects of rosiglitazone on peroxisome proliferator activated receptor-γ pathway in patients with chronic obstructive pulmonary disease].
To explore the effects of rosiglitazone on peroxisome proliferator activated receptor-γ (PPAR-γ), nuclear factor-κB and tumor necrosis factor-α (TNF-α) in patients with chronic obstructive pulmonary disease (COPD). ⋯ The expression and activity of PPAR-γ were decreased in COPD patients. PPAR-γ agonist rosiglitazone inhibited inflammation in COPD through upregulating the expression and activity of PPAR-γ and inhibition of NF-κB and TNF-α. It suggests that PPAR-γ may play an important role in the inflammation of COPD.