Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
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Conf Proc IEEE Eng Med Biol Soc · Jan 2008
Clinical TrialA neuro-fuzzy approach for predicting hemodynamic responses during anesthesia.
The effect of drugs' interaction on the hemo-dynamic variables is of great importance when considering patient's safety and stability. It is also important for control infusion systems during anesthesia. ⋯ The use of subtractive clustering improved the model performance on the testing data set. The fuzzy model is able to capture the synergistic interaction between the two drugs, but other influences were detected.
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Conf Proc IEEE Eng Med Biol Soc · Jan 2008
Fast prototype of a wireless cardiac rhythm interpretive instrument.
Extended patient monitoring has become increasingly important for detection of cardiac conditions, such as irregularities in the rhythms of the heart, while patient is practicing normal daily activity. This paper presents a design of a single lead wireless cardiac rhythm interpretive instrument that capable of capture the electrocardiogram (ECG) in digital format and transmitted to a remote base-station (i.e. PC) for storage and further interpretation. The design has achieved high quality of ECG and free of interference in the presence of motion.
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Conf Proc IEEE Eng Med Biol Soc · Jan 2008
Predicting ICU hemodynamic instability using continuous multiparameter trends.
Identifying hemodynamically unstable patients in a timely fashion in intensive care units (ICUs) is crucial because it can lead to earlier interventions and thus to potentially better patient outcomes. Current alert algorithms are typically limited to detecting dangerous conditions only after they have occurred and suffer from high false alert rates. Our objective was to predict hemodynamic instability at least two hours before a major clinical intervention (e.g., vasopressor administration), while maintaining a low false alert rate. ⋯ Area under receiver-operating curve (ROC) 0.83+/-0.03, sensitivity 0.75+/-0.06, and specificity 0.80+/-0.07; if the specificity is targeted at 0.90, then the sensitivity is 0.57+/-0.07. Based on our preliminary results, we conclude that the algorithms we developed using HR and BP trend data may provide a promising perspective toward reliable predictive alerts for hemodynamically unstable patients.
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Conf Proc IEEE Eng Med Biol Soc · Jan 2008
A target control Infusion method for neuromuscular blockade based on hybrid parameter estimation.
The paper presents a new method for target control infusion (TCI) for neuromuscular blockade (NMB) level control of patients subject to general anaesthesia. The method combines an inversion of the pharmacokinetic/pharmacodynamic (PK/PD) model with a hybrid parameter estimation method that uses on-line data from the initial bolus response to estimate the model parameters. Although atracurium is considered as relaxant, the newly proposed method may be applied to other drugs for which the PK/PD model is available. Simulation results on a bank of 100 patient models are presented to demonstrate the achievable performance.
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Conf Proc IEEE Eng Med Biol Soc · Jan 2008
Algorithm for automatic beat detection of cardiovascular pressure signals.
Pressure beat detection is an integral part of most analysis techniques for arterial blood pressure (ABP), intracranial pressure (ICP), and pulse oximetry (SpO(2)) signals. Beat detection has been used to estimate heart rate in the ABP signal, to classify ICP morphologies, and to estimate blood pressure using pulse oximeter waveforms. This paper describes an algorithm that was developed to detect pressure peak beats in ABP, ICP, and SpO(2) signals. When compared to the expert annotation of several signals consisting of over 42,500 pressure beats, the algorithm detected pressure peaks with an average sensitivity of 99.6% +/- 0.27 and an average positive predictivity of 98.6% +/- 1.1.