Revista médica de Chile
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Revista médica de Chile · May 1990
Review Case Reports[Lymphomatoid granulomatosis: a clinical case].
A 49 year old woman with a fluctuating painful ophthalmoplegia and a history of polyarthralgia is reported. On examination, additional findings included a maxillary subcutaneous infiltration, sphenoidal sinusitis and pulmonary nodes. Lung and sinus biopsy demonstrated findings compatible with lymphomatoid granulomatosis. The patient was treated with prednisone and cyclophosphamide, with good response of neurological and dermatological findings.
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Revista médica de Chile · Mar 1990
Case Reports[Acute post-partum infarct of the myocardium secondary to a spontaneous dissection of the coronary artery].
A 38 year-old woman had an anterolateral wall myocardial infarction and acute left ventricular failure 11 days after a cesarean section. Coronary angiography performed 14 days later because of recurrent angina disclosed dissection of the left main coronary artery. She subsequently underwent aorto coronary bypass surgery uneventfully. Spontaneous coronary artery dissection is a rare entity that mainly affects women in peripartum periods and presents a high mortality rate.
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Revista médica de Chile · Mar 1990
Case Reports[Use of a specific DNA probe to confirm sickle cell anemia in a caucasian woman].
A specific DNA probe containing part of the structural B-globulin gene was used to confirm the diagnosis of sickle cell anemia in a caucasian woman. The patient's genomic DNA was digested with the restriction endonuclease Dde I, fractioned by agarose electrophoresis and Southern blotting. Molecular hybridization was performed with the DNA probe prepared by chemical labelling with photobiotin. ⋯ Upon digestion with Dde I, the DNA of an individual with the normal genotype containing the enzyme recognition sequence at the site of sickle cell mutation, resulted in 2 fragments of 201 and 175 bp. The pedigree of the patient's caucasian family was studied by Hb electrophoresis. Four out of 7 brothers carried the sickle cell trait.
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Revista médica de Chile · Jan 1990
Clinical Trial[The effects of a dietary fiber (white lupine bran) in the treatment of non-insulin-dependent diabetes].
We evaluated the effect of dietary fiber from sweet lupine hull (SLH) upon metabolic control in 16 non insulin dependent diabetics (11 males, mean age 52). Body mass index was 23 +/- 2 and non fasting glucose levels were < 200 mg/dl. Following a 2 month control period, patients received SLH, 10 g th 3rd month and 20 g the fourth. ⋯ During the 4th month, blood glucose decreased to control levels. No changes were observed in body mass, HDL cholesterol, triglycerides, glycosylated Hb and non-fasting glucose and insulin levels in relation to fiber intake. We conclude that dietary fiber intake is low in our patients but a supplement of 10 to 20 g of this particular fiber did not improve metabolic control.
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Revista médica de Chile · Jan 1990
Comparative Study[The effect of anti-insulin antibodies and of peptide C residual secretion on the metabolic control of diabetes type 1].
In 20 type I diabetic patients treated with conventional insulin preparations, we measured insulin antibodies and peptide C secretion. Peptide C levels 90 and 120 min after a standard breakfast correlated well with glucosylated Hb levels (r = -0.48 and -0.52, respectively). ⋯ Metabolic control was not affected by insulin antibodies. Insulin dose decreased in relation to the duration of the disease and reduction of body weight index and was not correlated to glycosylated Hb levels.