Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology
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Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi · Dec 2009
[BTLA Characterization and its association with disease progression in patients with chronic HIV-1 infection.].
To characterize the B and T lymphocyte attenuator (BTLA, CD272) expression on CD4(+); and CD8(+); T lymphocytes during chronic HIV-1 infection, and analyze the clinical significance for its expression and disease progression. ⋯ BTLA signaling pathway may play an important role in the unbalance between the stimulating and inhibitory signal which results in the general immune activation during chronic HIV-1 infection. Manipulation of BTLA inhibitory pathway may present an alternative strategy for overcoming immune activation for this disease.
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Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi · Jun 2009
[Protective effects of continue insulin infusion on liver mitochondrion in the early stage of septic rats].
To investigate the protective effects of continue insulin infusion on liver mitochondrion and its mechanism in the early stage of lipopolysaccharide-induced septic rats. ⋯ In the early stage of septic rats, reversible liver mitochondrion injury can be observed. Continue insulin infusion can protect liver mitochondrion through attenuating inflammatory reaction and reducing the blood glucose level in septic rats.
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Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi · Jun 2008
[Soluble expression, purification and bioactivity of recombinant human Era protein].
To prepare a soluble human Era(hEra) protein and to measure its bioactivity. ⋯ Human Era protein can be expressed in a soluble form and it has been proved to be a kind of G protein by the experiments in vitro. The study is important to further research into the function of human era gene.
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Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi · May 2007
[Analysis of Foxp3+ CD4+ CD25+ regulatory cells in peripheral blood of patients with SLE].
To investigate the expression of GITR on T cells and the expression of Foxp3(+) CD4(+) CD25(+) regulatory T cells in the peripheral blood of patients with SLE. ⋯ The expression abnormality of both Foxp3(+) CD4(+) CD25(+) regulatory cells and GITR may play important role in the imbalance of immune homeostasis in SLE.
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Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi · Apr 2007
[Plasmid encoding human IL-12 improve protective efficacy of Mtb8.4 gene vaccine with signal sequence against infection of Mycobacterium Tuberculosis].
To study the specific celluar immune response and protective efficacy induced by co-immunization of DNA vaccine of Mtb8.4 with signal sequence (MS) and plasmid encoding human interleukin 12 (hIL-12). ⋯ Plasmid encoding hIL-12 can improve the specific cellular immune response and protective efficacy induced by the MS gene vaccine alone.