Dermatologica
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This study presents a case of two of the more uncommon side effects of bleomycin therapy for a metastasized testicular carcinoma: Raynaud's phenomenon and acral sclerosis. It is suggested that this association indicates a common pathogenic mechanism. These side effects may serve as an experimental model in the study of Raynaud's phenomenon and acral sclerosis.
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We report the case of a patient suffering from mycosis fungoides and plasma cell myeloma. It is postulated that this is not a fortuitous association, but that the B cell neoplasm evolved under the sustained inducer stimulus of the malignant T lymphocytes. This hypothesis is suggested by the demonstration of the helper phenotype of the cutaneous lymphocytes associated with a predominance of helper lymphocytes in blood.