BJOG : an international journal of obstetrics and gynaecology
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Comparative Study
The safety of ondansetron for nausea and vomiting of pregnancy: a prospective comparative study.
Ondansetron (Zofran) is a drug used for the treatment of nausea and vomiting caused by cancer chemotherapy. Despite the fact that it is not indicated, women are being prescribed this drug for the treatment of nausea and vomiting of pregnancy (NVP). There is a paucity of information on fetal safety for this indication. The objective of this study is to determine whether this drug increases the baseline rate of major malformations. ⋯ This drug does not appear (although the sample size is limited) to be associated with an increased risk for major malformations above baseline.
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Randomized Controlled Trial Comparative Study Clinical Trial
How long should urinary bladder catheterisation be continued after vaginal prolapse surgery? A randomised controlled trial comparing short term versus long term catheterisation after vaginal prolapse surgery.
To determine whether prolonged urinary bladder catheterisation after vaginal prolapse surgery is advantageous. ⋯ The disadvantages of prolonged catheterisation outweigh the advantages, therefore, removal of the catheter on the morning after surgery may be preferable and longer term catheterisation should only be undertaken where there are specific indications.
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Randomized Controlled Trial Comparative Study Clinical Trial
Home-based care after a shortened hospital stay versus hospital-based care postpartum: an economic evaluation.
To compare the cost effectiveness of early postnatal discharge and home midwifery support with a traditional postnatal hospital stay. ⋯ A policy of early postnatal discharge combined with home midwifery support exhibits weak economic dominance over traditional postnatal care, that is, it significantly reduces costs without compromising the health and wellbeing of the mother and infant.
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We set out to determine the current status of training in vaginal hysterectomy in the UK. In total, 255 year 4 or 5 'Calman' trainees were identified and sent an anonymous questionnaire assessing surgical experience, quality of training and attitudes towards vaginal hysterectomy. Our results demonstrate that senior trainees' experience in vaginal as opposed to abdominal hysterectomy is relatively poor. Despite this, trainees believed that the majority of hysterectomies should be done vaginally, and only a minority, laparoscopically.
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Randomized Controlled Trial Clinical Trial
A double blinded randomised placebo-controlled study of intramuscular pethidine for pain relief in the first stage of labour.
It has recently been suggested that systemic pethidine is ineffective in relieving labour pain. This study aims to evaluate the analgesic efficacy of pethidine in labour. ⋯ Systemic pethidine was more effective at relieving labour pain than placebo. Its analgesic effect, however, was modest.