BJOG : an international journal of obstetrics and gynaecology
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Randomized Controlled Trial Multicenter Study
Diagnostic workup for postmenopausal bleeding: a randomised controlled trial.
To evaluate the effectiveness of hysteroscopy for the detection and treatment of endometrial polyps versus expectant management in women with postmenopausal bleeding (PMB), a thickened endometrium and benign endometrial sampling. ⋯ In women with PMB, hysteroscopy does not reduce recurrent bleeding but is warranted to detect focal malignancy.
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Localised provoked vulvodynia (LPV) is a common, chronic, and disabling condition: patients experience profound pain and a diminished quality of life. The aetiologic origins of vulvodynia are poorly understood, yet recent evidence suggests a link to site-specific inflammatory responses. ⋯ Although LPV is a multifactorial disorder, understanding vulvar inflammation and targeting the inflammatory response should lead to treatment advances, especially for patients exhibiting signs of inflammation. NFκB (already targeted clinically) or other inflammatory components may be suitable therapeutic targets.
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The contraceptive injectable is a safe and effective method that is used worldwide. With the variety of injectable delivery systems, there is potential for administration by the woman herself. Self-administration of the contraceptive injectable is the subject of this systematic review. ⋯ This review assessed the continuation rates and safety of self-administration of the contraceptive injection.
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To ascertain the incidence of massive transfusion (MT) in obstetrics in the UK, and describe its management and clinical outcomes. ⋯ Massive transfusion due to postpartum haemorrhage is associated with high rates of morbidity and hysterectomy.
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To evaluate whether in symptomatic women, the combination of quantitative fetal fibronectin (fFN) testing and cervical length (CL) improves the prediction of preterm delivery (PTD) within 7 days compared with qualitative fFN and CL. ⋯ Quantitative fFN testing adds value to qualitative fFN testing with CL measurement in the prediction of PTD.