Acta pharmacologica Sinica
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Acta Pharmacol. Sin. · Jun 2011
ReviewMaternal-fetal fluid balance and aquaporins: from molecule to physiology.
Maternal-fetal fluid balance is critical during pregnancy, and amniotic fluid is essential for fetal growth and development. The placenta plays a key role in a successful pregnancy as the interface between the mother and her fetus. Aquaporins (AQPs) form specific water channels that allow the rapid transcellular movement of water in response to osmotic/hydrostatic pressure gradients. AQPs expression in the placenta and fetal membranes may play important roles in the maternal-fetal fluid balance.
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Acta Pharmacol. Sin. · Feb 2011
Kynurenic acid attenuates multiorgan dysfunction in rats after heatstroke.
To assess whether systemic delivery of kynurenic acid improves the outcomes of heatstroke in rats. ⋯ Our results suggest that systemic delivery of kynurenic acid may attenuate multiorgan dysfunction in rats after heatstroke.
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Acta Pharmacol. Sin. · Oct 2010
Enhanced pressor response to acute Ang II infusion in mice lacking membrane-associated prostaglandin E2 synthase-1.
To examine the contribution of vascular membrane-associated prostaglandin E2 synthase-1 (mPGES-1) to acute blood pressure homeostasis. ⋯ Vascular mPGES-1 acts as an important tonic vasodilator, contributing to acute blood pressure regulation.
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Acta Pharmacol. Sin. · Aug 2010
Comparative StudyIntracisternal or intrathecal glycine, taurine, or muscimol inhibit bicuculline-induced allodynia and thermal hyperalgesia in mice.
To investigate the effects of GABA and glycine on analgesia in the central nervous system. ⋯ Glycine, taurine, and muscimol were found to have anti-allodynic and anti-thermal hyperalgesic properties in vivo. These observations suggest an interaction between glycine and GABA receptors during the regulation of antinociception.
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Acta Pharmacol. Sin. · Jul 2010
Angiopoiesis and bone regeneration via co-expression of the hVEGF and hBMP genes from an adeno-associated viral vector in vitro and in vivo.
To investigate the therapeutic potential of adeno-associated virus (AAV)-mediated expression of vascular endothelial growth factor (VEGF) and bone morphogenetic protein (BMP). ⋯ AAV-mediated VEGF and BMP gene transfer stimulates angiogenesis and bone regeneration and may be a new therapeutic technique for the treatment of avascular necrosis of the femoral head (ANFH).