Articles: opioid-analgesics.
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Comparative Study
Association Between Preoperative Benzodiazepine Use and Postoperative Opioid Use and Health Care Costs.
The association between preoperative benzodiazepine use and long-term postoperative outcomes is not well understood. ⋯ The findings of this study suggest that, among opioid-naive patients, preoperative benzodiazepine use may be associated with an increased risk of developing long-term opioid use and increased opioid dosages postoperatively, and also may be associated with increased health care costs.
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The chronic use of opioids and glucocorticoids is associated with serious side effects. Moreover, both medications are related to poor long-term postoperative outcomes. ⋯ Chronic pre-operative use of opioids and glucocorticoids, together or individually, were associated with increased 90-day mortalities after noncardiac surgery, compared with opioid-naïve and glucocorticoid-naïve patients. Our results suggest that chronic pre-operative use of opioids and glucocorticoids should be managed carefully.