Articles: female.
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Pol. Arch. Med. Wewn. · Dec 2024
Sex differences in cardiovascular outcomes in patients with acute pancreatitis.
The risk of cardiovascular disease increases in patients with acute pancreatitis (AP). However, it remains unknown whether this increase varies between sexes. ⋯ Men experienced more adverse cardiovascular outcomes than women in long follow‑up after AP, suggesting a need for sex‑specific management strategies in AP patients.
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Previous preclinical and translational studies suggest that tissue trauma related to bony fracture and intervertebral disk disruption initiates the formation of pronociceptive antibodies that support chronic musculoskeletal pain conditions. This study tested this hypothesis in the monosodium iodoacetate (MIA) mouse model of osteoarthritis (OA) and extended the findings using OA patient samples. Monosodium iodoacetate was injected unilaterally into the knees of male and female wild-type (WT) and muMT mice (lacking B cells) to induce articular cartilage damage. ⋯ Similarly, intra-articular injection of IgM from patients with OA was pronociceptive in muMT MIA mice and control subject IgM had no effect. Monosodium iodoacetate-injected joints demonstrate elevated levels of complement component 5a (C5a) and C5a receptor blockade using intra-articular PMX-53-reduced sensitization. These data suggest that MIA-treated mice and patients with OA generate pronociceptive antibodies, and further support the pronociceptive autoimmunity hypothesis for the transition from tissue injury to chronic musculoskeletal pain.
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Retrospective study analysis. ⋯ Our study demonstrated FJOA, PI, age, and female were associated with paraspinal sarcopenia. The assessments of paraspinal muscles cross-sectional area were not associated with the severity of fatty infiltration.