Articles: sars-cov-2.
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Eur. J. Intern. Med. · Jan 2024
Global burden of new-onset hypertension associated with severe acute respiratory syndrome coronavirus 2 infection.
Several reports documented a specific effect of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on blood pressure (BP), during and after the acute phase of infection. Clinical studies demonstrated that coronavirus disease 2019 (COVID-19) is associated with an increased risk of a persistent increase in BP requiring a new or intensified anti-hypertensive treatment during hospitalization. The picture is further complicated by the evidence from large databases showing an increased risk of new-onset hypertension in COVID-19 survivors on the long term. ⋯ In both the acute phase and recovery from infection, the interaction between spike proteins of SARS-CoV-2 and angiotensin converting enzyme 2 (ACE2) receptors remain the most plausible mechanism explaining the raise in BP (ranking new onset hypertension as one of the most prevalent cardiovascular sequelae of COVID-19). In this area of research, it is worth to mention that new variants of SARS-CoV-2 exhibit specific mutations in the spike protein that promotes entry into viral cells via ACE2. Thus, the enhanced spike affinity for ACE2 of new variants has the potential to increase the risk of new-onset hypertension when compared with the original Wuhan strain.
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The aim of the study is to determine the prevalence and factors associated with olfactory dysfunction in individuals with COVID-19 in the first 2 years of the pandemic in Brazil. ⋯ The prevalence of olfactory disorders was lower compared to other studies, with cough and fever being negatively related to olfactory dysfunction and headache, coryza, and taste disorders being positively related. Obesity was the only associated comorbidity.
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Post-acute sequelae of SARS-CoV-2 (PASC) are known for their prolonged and persistent effects on patients. This study aimed to investigate the impact of the PASC on the quality of life (QOL) of patients, their levels of activity participation, and satisfaction with these levels, in addition to exploring whether the duration of post-intensive care unit (ICU) discharge is associated with the effects of PASC. ⋯ PASC adversely affected the daily functioning of patients, especially in leisure, social, and religious aspects. However, these effects lessened over time, with corresponding improvement in QOL. Additionally, patient satisfaction with functional performance increased over time. These findings shed light on the rehabilitation needs of patients with COVID-19.
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The aim of this study was to analyse the group of newborns who were admitted at Neonatal Department of Intensive Medicine in Bratislava Faculty of Medicine Comenius University in Bratislava and National Institute of Children´s Diseases in the period from 08.01.2021 until 07.07.2023 who were affected by the COVID-19 virus from mother before birth, from staff or in family or were only in contact with COVID-19 positive person. ⋯ COVID-19 pandemic had a great impact on the pregnant women as well as on prenatal and postnatal development of the child. Our results reveal that the severity of symptoms in COVID-19 infected newborns from our sample was low. It is important to implement adequate neonatal practices for early detection of illnesses, especially in relation to COVID-19 which will subsequently allow early intervention and reduce neonatal mortality. Future challenges for all countries include the implementation of higher hygiene standards, prevention of spreading, more sensitive tests to use in the first day of life (Tab. 3, Ref. 36).
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The effect of SARS-CoV-2 infection on the liver during pregnancy and the impact of SARS-COV-2-related liver injury during pregnancy on obstetric and neonatal outcomes are not yet clear. The aim of this study was to determine the clinical features of pregnant women at risk of liver injury and to investigate the effect of liver dysfunction on obstetric and perinatal outcomes. ⋯ Our study showed that pregnant patients with liver damage had worse inflammatory response than those without liver damage. Women with elevated liver enzymes tend to have severe disease, but obstetric and perinatal outcomes were similar between groups with and without liver damage.