Articles: respiratory-distress-syndrome.
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Z Erkr Atmungsorgane · Jan 1989
Comparative StudyIncrease of the oxygenation and decrease of the intrapulmonary peak pressure at constant mean airway pressure using high-frequency jet ventilation in adult rabbits with lavage-induced severe respiratory distress syndrome compared to conventional mechanical ventilation.
Reports are contradictory about the value of high-frequency jet ventilation (HFJV) in the treatment of respiratory distress syndrome (RDS) [10, 11, 18 - 1, 2, 22, 25]. In a preliminary study on rabbits with healthy as well as surfactant deficient lungs, caused by lung lavage, at a constant mean airway pressure (MAP) and 20% inspiration time, the influence of the jet ventilation frequencies of 1, 3, 5, 10, 15 and 20 Hz (cycles per second) on the pressure oscillations along the airways as well as on blood gas and cardiac parameters were investigated. It was presumed that the breathing level, e.g. functional residual capacity plus 50% of the tidal volume is the same at constant MAP. ⋯ Optimal gas exchange could be obtained at about 10 Hz. Decreasing cardiac output with increasing frequency showed a good correlation to the pH in both groups. The effect was more influenced by the heart frequency than by the stroke volume especially in the RDS-group.
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A case of the shock lung with numerous hyalin membranes is described in a 19-year-old woman after the delivery with a consequent acute respiratory failure. Bacterial shock, acute respiratory disease, possible embolism with amniotic fluid in combination with hypercoagulation typical for pregnancy are named among the causes of the shock lung development. A partial resolution and marked organization of the hyalin membranes are observed.
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The Journal of pediatrics · Dec 1988
Abnormalities of diaphragmatic muscle in neonates with ventilated lungs.
Several infants and neonates who had received long-term ventilatory assistance had subnormal diaphragmatic muscle mass on gross necropsy examination. We conducted a retrospective study of our hospital infant necropsy files to determine whether prolonged ventilatory support was associated with diminution in myofiber cross-sectional area selectively affecting the diaphragm. We found that long-term ventilatory assistance may predispose diaphragmatic myofibers to disuse atrophy or to failure or normal growth. This phenomenon may contribute to difficulties in weaning infants from ventilatory support.