• Nutrition · Mar 2021

    Plasma metabolomics are associated with metabolic syndrome: A targeted approach.

    • Carioca Antonio Augusto Ferreira AAF Department of Nutrition, School of Public Health, University of Sao Paulo, SP, Brazil; University of Fortaleza (UNIFOR), Nutrition Co, Josiane Steluti, Aline Martins de Carvalho, Alexsandro Macedo Silva, Silva Ismael Dale Cotrim Guerreiro da IDCGD Department of Gynecology, Paulista School of Medicine, Federal University of Sao Paulo, SP, Brazil., Regina Mara Fisberg, and Dirce Maria Marchioni.
    • Department of Nutrition, School of Public Health, University of Sao Paulo, SP, Brazil; University of Fortaleza (UNIFOR), Nutrition Course, Fortaleza, Brazil. Electronic address: carioca@unifor.br.
    • Nutrition. 2021 Mar 1; 83: 111082.

    ObjectivesAdvances in metabolomic tools have allowed us to gain a more comprehensive understanding of metabolic syndrome (MetS). The aim of this study was to evaluate the association between plasma metabolomic profiles and MetS.MethodsFor this study, adults without diabetes, chronic kidney disease, stroke, heart disease, or cancer and with full metabolomics, biochemical, and dietetic data available, representing a subsample of the Health Survey of Sao Paulo study (ISA-Capital; N = 130), were included. The joint interim statement consensus criteria were used for diagnosing MetS. Absolute quantification (µmol/L) of blood metabolites was achieved by targeted quantitative profiling of annotated metabolites by electrospray ionization tandem mass spectrometry in plasma samples. Mean differences in the compounds for MetS were evaluated by linear regression adjusted for confounding factors.ResultsSerine was inversely associated with MetS (β = -15.04; P = 0.014). In glycerophospholipids with acyl-alkyl bonds, there was an inverse association with MetS, including phosphatidylcholine (PC) ae C42:5 (β = -0.15; P = 0.040), PC ae C44:5 (β = -0.15; P = 0.046), PC ae C40:4 (β = -0.21; P = 0.014) and PC ae C44:4 (β = -0.04; P = 0.032).ConclusionPlasma metabolomic profiles were associated with MetS, especially the amino acid serine and some acyl-alkyl PCs.Copyright © 2020 Elsevier Inc. All rights reserved.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…