Annals of internal medicine
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Randomized Controlled Trial Multicenter Study Clinical Trial
Lack of pharmacologic tolerance and rebound angina pectoris during twice-daily therapy with isosorbide-5-mononitrate.
To determine whether isosorbide-5-mononitrate (IS-5-MN), an active metabolite of isosorbide dinitrate, when given twice daily (in the morning and 7 hours later), prevents development of tolerance and reduction in exercise performance or is associated with a rebound increase in anginal attacks in patients with stable angina pectoris. ⋯ Isosorbide-5-mononitrate, 20 mg twice daily given 7 hours apart, was well tolerated and improved exercise performance for 7 hours after the morning dose and for 5 hours after the afternoon dose without evidence of development of pharmacologic tolerance. No rebound increase in anginal attacks was found.
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Randomized Controlled Trial Clinical Trial
Predictors of smoking cessation after coronary artery bypass graft surgery. Results of a randomized trial with 5-year follow-up.
To test the efficacy of a smoking cessation program for inpatients recovering from coronary artery bypass graft surgery and to identify predictors of cessation. ⋯ Even without specific intervention, nearly one half of smokers quit for 5 years after coronary artery bypass surgery. A short inpatient education program did not increase this rate. Future efforts should target the time after discharge and focus on increasing motivation in patients who have repeatedly failed to quit.
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Randomized Controlled Trial Comparative Study Clinical Trial
The weight-based heparin dosing nomogram compared with a "standard care" nomogram. A randomized controlled trial.
To determine whether an intravenous heparin dosing nomogram based on body weight achieves therapeutic anticoagulation more rapidly than a "standard care" nomogram. ⋯ The weight-based heparin nomogram is widely generalizable and has proved to be effective, safe, and superior to one based on standard practice.
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Randomized Controlled Trial Clinical Trial
Subcutaneous morphine for dyspnea in cancer patients.
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Randomized Controlled Trial Clinical Trial
Efficacy of psyllium in reducing serum cholesterol levels in hypercholesterolemic patients on high- or low-fat diets.
To determine the efficacy of psyllium in reducing serum cholesterol levels in patients on high- or low-fat diets. ⋯ Psyllium produces a modest but significant improvement in total cholesterol and LDL cholesterol levels in persons on either low-fat or high-fat diets. Psyllium, when added to a prescribed low-fat diet, may obviate the need for typical lipid-lowering medications or may prove to be a valuable adjunct to other treatments in patients with moderately elevated LDL cholesterol levels.