Annals of internal medicine
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Comment Meta Analysis
In CV disease, clopidogrel reduces nonfatal MI and MACE vs. aspirin but not stroke or mortality.
Tasoudis PT, Kyriakoulis IG, Sagris D, et al. Clopidogrel monotherapy versus aspirin monotherapy in patients with established cardiovascular disease: systematic review and meta-analysis. Thromb Haemost. 2022;122:1879-87. 35577054.
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The effectiveness of screening for colorectal cancer (CRC) by sex and age in randomized trials is uncertain. ⋯ Health Fund of South-East Norway.
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Review Case Reports Meta Analysis
The Impact of the COVID-19 Pandemic and Associated Control Measures on the Mental Health of the General Population : A Systematic Review and Dose-Response Meta-analysis.
To what extent the COVID-19 pandemic and its containment measures influenced mental health in the general population is still unclear. ⋯ Swiss National Science Foundation. (PROSPERO: CRD42020180049).
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Review Meta Analysis
Effectiveness of Opioid Analgesic Medicines Prescribed in or at Discharge From Emergency Departments for Musculoskeletal Pain : A Systematic Review and Meta-analysis.
The comparative benefits and harms of opioids for musculoskeletal pain in the emergency department (ED) are uncertain. ⋯ None. (PROSPERO: CRD42021275293).
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Comment Meta Analysis
In adults using oral anticoagulants, PPI use may be associated with lower risk for upper GI bleeding.
Kurlander JE, Barnes GD, Fisher A, et al. Association of antisecretory drugs with upper gastrointestinal bleeding in patients using oral anticoagulants: a systematic review and meta-analysis. Am J Med. 2022;135:1231-43.e8. 35679879.