Arch Neurol Chicago
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Arch Neurol Chicago · Feb 2007
Comparative StudyDifferentiation between primary lateral sclerosis and amyotrophic lateral sclerosis: examination of symptoms and signs at disease onset and during follow-up.
Motor neuron diseases can affect the upper motor neuron and/or the lower motor neuron. Both amyotrophic lateral sclerosis (ALS) and primary lateral sclerosis (PLS) are motor neuron diseases, and there is much debate as to whether these are 2 separate disorders or simply 2 points on a continuum. ⋯ Our findings suggest that a patient presenting with spasticity who does not develop wasting within 3 years most likely has PLS.
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Arch Neurol Chicago · Feb 2007
Comparative StudyDeep gray matter perfusion in multiple sclerosis: dynamic susceptibility contrast perfusion magnetic resonance imaging at 3 T.
To assess the presence of perfusion abnormalities in the deep gray matter of patients with relapsing-remitting and primary progressive multiple sclerosis (MS) in comparison with healthy controls and to investigate the impact of perfusion impairment on clinical disability and fatigue. ⋯ The decrease of tissue perfusion in the deep gray matter of patients with MS is associated with the severity of fatigue.
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Arch Neurol Chicago · Jan 2007
Case ReportsOrnithine transcarbamylase deficiency presenting as encephalopathy during adulthood following bariatric surgery.
Neurological complications following bariatric surgery are rare. Whereas nutritional deficiencies are the most common cause of neurological symptoms, the unmasking of previously subclinical metabolic disorders can also lead to significant morbidity. ⋯ Previously asymptomatic ornithine transcarbamylase deficiency should be suspected in adult patients who develop recurrent hyperammonemia and encephalopathy following bariatric surgery.
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Arch Neurol Chicago · Dec 2006
Randomized Controlled TrialFactors associated with the development of motor fluctuations and dyskinesias in Parkinson disease.
Motor fluctuations and dyskinesias can cause disability and reduce quality of life for patients with Parkinson disease (PD). ⋯ Higher cumulative levodopa doses and higher cumulative levodopa equivalent doses (levodopa plus pramipexole) were associated with the earlier occurrence of motor complications. Motor fluctuations and dyskinesias appear to be interrelated because the presence of one is associated with the earlier development of the other.