Articles: coronavirus.
-
There is an urgent need for safe and effective approaches to combat COVID-19. Here, we asked whether lessons learned from nanotoxicology and nanomedicine could shed light on the current pandemic. SARS-CoV-2, the causative agent, may trigger a mild, self-limiting disease with respiratory symptoms, but patients may also succumb to a life-threatening systemic disease. ⋯ Moreover, recent work has shown that synthetic nanoparticles wrapped with host-derived cellular membranes may prevent virus infection. We posit that nanoparticles decorated with ACE2, the receptor for SARS-CoV-2, could be exploited as decoys to intercept the virus before it infects cells in the respiratory tract. However, close attention should be paid to biocompatibility before such nano-decoys are deployed in the clinic.
-
Respiratory medicine · Oct 2020
COVID-19 patients in a tertiary US hospital: Assessment of clinical course and predictors of the disease severity.
Patients with severe COVID-19 can develop ventilator-dependent acute hypoxic respiratory failure (VDAHRF), which is associated with a higher mortality rate. We evaluated the clinical course of hospitalized COVID-19 patients and compared them with the patients who received invasive mechanical ventilation. Characteristics of intubated patients who were successfully weaned from the ventilator were compared with the patients who failed to be extubated or died in the hospital. ⋯ Patients who required invasive mechanical ventilation were more likely to have older age, male gender, coronary artery disease, diabetes, and obesity. The patients who were successfully weaned from the ventilator were more likely to be younger in age, and none of them had heart failure or CAD.
-
J Coll Physicians Surg Pak · Oct 2020
Coronavirus Disease 2019 (COVID-19) Mechanical Ventilation Research Theme Analysis: Co-word Cluster Analysis.
The objective of this analysis was to explore the research hotspot of coronavirus disease 2019 (COVID-19) mechanical ventilation. The literature related to COVID-19 mechanical ventilation on PubMed and CNKI database of core journals was retrieved with the keyword of COVID-19 mechanical ventilation. The visualisation software of VOS (visualisation of similarities) viewer performed by the authors and high-frequency keywords. ⋯ The literature yeilded by PubMed paid attention to the factors affecting the poor prognosis of mechanically ventilated patients, the management and research and development of medical data during COVID-19's pandemic, the mechanical ventilation treatment of COVID-19 pregnant women, the mechanical ventilation treatment and nursing in the field of CNKI literature research, and the nutritional treatment of severe pneumonia patients with mechanical ventilation. The current COVID-19 researches, focused on the prevention of nosocomial infection and antiviral drugs in the process of mechanical ventilation, are a new hotspot in the world. Key Words: Coronavirus disease 2019 (COVID-19), Mechanical ventilation, Research hotspot, VOSviewer, Visual analysis.
-
To retrospectively analyze the chest computed tomography (CT) features in patients with coronavirus disease 2019 (COVID-19) pneumonia. ⋯ • The predominant CT features of COVID-19 pneumonia are multiple ground-glass opacities with or without consolidation and, with both lungs, multiple lobes and especially the lower lobe affected. • CT plays a crucial role in early diagnosis and assessment of COVID-19 pneumonia progression. • CT findings of COVID-19 pneumonia may not be consistent with the clinical symptoms or the initial RT-PCR test results.